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Scientific article
English

The Ace locus of Drosophila melanogaster: structural gene for acetylcholinesterase with an unusual 5' leader

Contributors

Hall, Lucinda M. C.; Spierer, Pierre

Published in

EMBO journal, vol. 5, no. 11, p. 2949-2954

Publication date

1986

Abstract

The Ace locus of Drosophila melanogaster has been mapped at the molecular level. cDNA clones from the locus have been isolated and their sequence determined, confirming that Ace forms the structural gene for acetylcholinesterase (AChE). The cDNAs have a 1950 nucleotide open reading frame from which the complete amino acid sequence of AChE has been deduced. The Drosophila enzyme is found to have extensive homology to the known sequence of Torpedo AChE. Ace cDNAs have an unusual structure with a long 5' leader and several short upstream open reading frames.

Keywords

  • Acetylcholinesterase/genetics
  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • DNA Restriction Enzymes
  • Drosophila melanogaster/enzymology/genetics
  • Genes
  • Protein Sorting Signals/analysis
  • Transcription, Genetic

UNIGE affiliation entities

Citation (ISO format)

HALL, Lucinda M. C., SPIERER, Pierre. The Ace locus of Drosophila melanogaster: structural gene for acetylcholinesterase with an unusual 5′ leader. In: EMBO journal, 1986, vol. 5, n° 11, p. 2949–2954. doi: 10.1002/j.1460-2075.1986.tb04591.x

Main files (1)

Article (Published version)

Identifiers

Journal ISSN

0261-4189
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Technical informations

Creation

27/07/2010 15:08:00

First validation

27/07/2010 15:08:00

Update

13/03/2026 08:22:39

Status update

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Last indexation

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