UNIGE document Scientific Article - Letter
previous document  unige:9860  next document
add to browser collection

Genes and loops in 320,000 base-pairs of the Drosophila melanogaster chromosome

Published in Journal of Molecular Biology. 1986, vol. 190, no. 2, p. 255-258
Abstract We have mapped the DNA sequences bound to the nuclear scaffold along 320,000 base-pairs of a genetically well-defined region of the Drosophila chromosome. We have found that the domains delimited by the scaffold attachment regions are heterogeneous in size (ranging from 26,000 to 112,000 base-pairs in this interval), and that the attachment sites are within unique sequences as judged by blot hybridization. We also found that looped domains contain up to five, or even eight, unrelated genes including, in some cases, more than one transcribed gene. The loop organization unravelled here in cultured cells does not correspond to the banding pattern seen in salivary gland polytene chromosomes.
Keywords AnimalsBase SequenceChromosome BandingChromosomes/ultrastructureDNA/geneticsDrosophila melanogaster/geneticsGenes
PMID: 3098982
Full text
Article (Published version) (2.3 MB) - document accessible for UNIGE members only Limited access to UNIGE
(ISO format)
MIRKOVITCH, Jovan, SPIERER, Pierre, LAEMMLI, Ulrich Karl. Genes and loops in 320,000 base-pairs of the Drosophila melanogaster chromosome. In: Journal of Molecular Biology, 1986, vol. 190, n° 2, p. 255-258. doi: 10.1016/0022-2836(86)90296-2 https://archive-ouverte.unige.ch/unige:9860

509 hits

0 download


Deposited on : 2010-08-06

Export document
Format :
Citation style :