UNIGE document Scientific Article
previous document  unige:9860  next document
add to browser collection
Title

Genes and loops in 320,000 base-pairs of the Drosophila melanogaster chromosome

Authors
Mirkovitch, Jovan
Laemmli, Ulrich K.
Published in Journal of Molecular Biology. 1986, vol. 190, no. 2, p. 255-8
Abstract We have mapped the DNA sequences bound to the nuclear scaffold along 320,000 base-pairs of a genetically well-defined region of the Drosophila chromosome. We have found that the domains delimited by the scaffold attachment regions are heterogeneous in size (ranging from 26,000 to 112,000 base-pairs in this interval), and that the attachment sites are within unique sequences as judged by blot hybridization. We also found that looped domains contain up to five, or even eight, unrelated genes including, in some cases, more than one transcribed gene. The loop organization unravelled here in cultured cells does not correspond to the banding pattern seen in salivary gland polytene chromosomes.
Keywords AnimalsBase SequenceChromosome BandingChromosomes/ultrastructureDNA/geneticsDrosophila melanogaster/geneticsGenes
Identifiers
PMID: 3098982
Full text
This document has no fulltext available yet, but you can contact its author by using the form below.
Structures
Citation
(ISO format)
MIRKOVITCH, Jovan, SPIERER, Pierre, LAEMMLI, Ulrich K. Genes and loops in 320,000 base-pairs of the Drosophila melanogaster chromosome. In: Journal of Molecular Biology, 1986, vol. 190, n° 2, p. 255-8. https://archive-ouverte.unige.ch/unige:9860

216 hits

0 download

Update

Deposited on : 2010-08-06

Export document
Format :
Citation style :