Scientific article

Genes and loops in 320,000 base-pairs of the Drosophila melanogaster chromosome

Published inJournal of Molecular Biology, vol. 190, no. 2, p. 255-258
Publication date1986

We have mapped the DNA sequences bound to the nuclear scaffold along 320,000 base-pairs of a genetically well-defined region of the Drosophila chromosome. We have found that the domains delimited by the scaffold attachment regions are heterogeneous in size (ranging from 26,000 to 112,000 base-pairs in this interval), and that the attachment sites are within unique sequences as judged by blot hybridization. We also found that looped domains contain up to five, or even eight, unrelated genes including, in some cases, more than one transcribed gene. The loop organization unravelled here in cultured cells does not correspond to the banding pattern seen in salivary gland polytene chromosomes.

  • Animals
  • Base Sequence
  • Chromosome Banding
  • Chromosomes/ultrastructure
  • DNA/genetics
  • Drosophila melanogaster/genetics
  • Genes
Citation (ISO format)
MIRKOVITCH, Jovan, SPIERER, Pierre, LAEMMLI, Ulrich Karl. Genes and loops in 320,000 base-pairs of the <i>Drosophila melanogaster</i> chromosome. In: Journal of Molecular Biology, 1986, vol. 190, n° 2, p. 255–258. doi: 10.1016/0022-2836(86)90296-2
Main files (1)
Article (Published version)
ISSN of the journal0022-2836

Technical informations

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