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Pancreatic alpha cell-selective deletion of Tcf7l2 impairs glucagon secretion and counter-regulatory responses to hypoglycaemia in mice

Publié dansDiabetologia, vol. 60, no. 6, p. 1043-1050
Date de publication2017
Résumé

Transcription factor 7-like 2 (TCF7L2) is a high mobility group (HMG) box-containing transcription factor and downstream effector of the Wnt signalling pathway. SNPs in the TCF7L2 gene have previously been associated with an increased risk of type 2 diabetes in genome-wide association studies. In animal studies, loss of Tcf7l2 function is associated with defective islet beta cell function and survival. Here, we explore the role of TCF7L2 in the control of the counter-regulatory response to hypoglycaemia by generating mice with selective deletion of the Tcf7l2 gene in pancreatic alpha cells.

Citation (format ISO)
DA SILVA XAVIER, Gabriela et al. Pancreatic alpha cell-selective deletion of Tcf7l2 impairs glucagon secretion and counter-regulatory responses to hypoglycaemia in mice. In: Diabetologia, 2017, vol. 60, n° 6, p. 1043–1050. doi: 10.1007/s00125-017-4242-2
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ISSN du journal0012-186X
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Création20/07/2017 11:13:00
Première validation20/07/2017 11:13:00
Heure de mise à jour15/03/2023 02:15:38
Changement de statut15/03/2023 02:15:37
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