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Title

Pancreatic alpha cell-selective deletion of Tcf7l2 impairs glucagon secretion and counter-regulatory responses to hypoglycaemia in mice

Authors
da Silva Xavier, Gabriela
Mondragon, Angeles
Mourougavelou, Vishnou
Cruciani-Guglielmacci, Céline
Denom, Jessica
Magnan, Christophe
Rutter, Guy A
Published in Diabetologia. 2017, vol. 60, no. 6, p. 1043-1050
Abstract Transcription factor 7-like 2 (TCF7L2) is a high mobility group (HMG) box-containing transcription factor and downstream effector of the Wnt signalling pathway. SNPs in the TCF7L2 gene have previously been associated with an increased risk of type 2 diabetes in genome-wide association studies. In animal studies, loss of Tcf7l2 function is associated with defective islet beta cell function and survival. Here, we explore the role of TCF7L2 in the control of the counter-regulatory response to hypoglycaemia by generating mice with selective deletion of the Tcf7l2 gene in pancreatic alpha cells.
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PMID: 28343277
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Article (Published version) (1.4 MB) - public document Free access
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Research group Types cellulaires pancréatiques pendant l'ontogénèse (522)
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DA SILVA XAVIER, Gabriela et al. Pancreatic alpha cell-selective deletion of Tcf7l2 impairs glucagon secretion and counter-regulatory responses to hypoglycaemia in mice. In: Diabetologia, 2017, vol. 60, n° 6, p. 1043-1050. https://archive-ouverte.unige.ch/unige:98523

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Deposited on : 2017-11-03

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