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Scientific article
English

Extracellular Vesicles in Bile as Markers of Malignant Biliary Stenoses

ContributorsSeverino, Valeria; Dumonceau, Jean-Marc; Delhaye, Myriam; Moll, Solange; Annessi Ramseyer, Isabelle; Robin, Xavier Arnaud; Frossard, Jean-Louis; Farina, Annarita
Published inGastroenterology, vol. 153, no. 2, p. 495-504.e8
Publication date2017
Abstract

Algorithms for diagnosis of malignant common bile duct (CBD) stenoses are complex and lack accuracy. Malignant tumors secrete large numbers of extracellular vesicles (EVs) into surrounding fluids; EVs might therefore serve as biomarkers for diagnosis. We investigated whether concentrations of EVs in bile could discriminate malignant from nonmalignant CBD stenoses.

Keywords
  • Adult
  • Aged
  • Aged, 80 and over
  • Bile
  • Bile Duct Neoplasms/complications/diagnosis
  • Biomarkers, Tumor/analysis
  • Cholangiocarcinoma/complications/diagnosis
  • Cholestasis/diagnosis/etiology
  • Europe
  • Extracellular Vesicles
  • Female
  • Gallstones/diagnosis
  • Humans
  • Male
  • Middle Aged
  • Pancreatic Neoplasms/complications/diagnosis
  • Pancreatitis, Chronic/complications/diagnosis
  • Prospective Studies
  • ROC Curve
Affiliation entities
Research groups
Citation (ISO format)
SEVERINO, Valeria et al. Extracellular Vesicles in Bile as Markers of Malignant Biliary Stenoses. In: Gastroenterology, 2017, vol. 153, n° 2, p. 495–504.e8. doi: 10.1053/j.gastro.2017.04.043
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
Journal ISSN0016-5085
851views
4downloads

Technical informations

Creation08/09/2017 16:43:00
First validation08/09/2017 16:43:00
Update03/02/2025 08:53:38
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