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Vitamin D and cognitive functioning in the elderly population in Germany

Breitling, Lutz P.
Perna, Laura
Müller, Heiko
Raum, Elke
Brenner, Hermann
Published in Experimental Gerontology. 2012, vol. 47, no. 1, p. 122-127
Abstract To examine the relationship of serum 25-hydroxy vitamin D3 with cognitive functioning in higher age, using an instrument covering multiple cognitive domains in a population-based study. Follow-up study with measurement of vitamin D levels at baseline and assessment of cognitive functioning at year 5 follow-up. A subgroup of 1639 participants of the ongoing epidemiological ESTHER study of the elderly general population in Saarland State, Germany, aged 65+ years at baseline (2000–2002). Observational study. Cognitive functioning was assessed by the COGTEL phone interview developed by Kliegel et al., which was administered 5years after ESTHER baseline. Vitamin D in baseline samples was measured by chemiluminescence methods. Additional information was obtained by standardised questionnaires. In multiple linear regression adjusted for important confounders, women in the lowest sex-specific quintile of vitamin D showed an on average 2.1 (95% confidence interval: 0.4 to 3.9) units lower COGTEL score than women in the highest quintile. A similar, albeit slightly weaker, association was seen in males (difference of 1.7 [−0.4 to 3.8] units). Spline regression suggested non-linearity with a distinct decline in cognitive performance in the lower range of vitamin D levels. Our findings support suggestions that low levels of vitamin D may be associated with reduced cognitive functioning in the elderly.
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BREITLING, Lutz P. et al. Vitamin D and cognitive functioning in the elderly population in Germany. In: Experimental Gerontology, 2012, vol. 47, n° 1, p. 122-127. https://archive-ouverte.unige.ch/unige:98380

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