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Cardiovascular Manifestations of Hepatitis C Virus

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Published in Clinics in Liver Disease. 2017, vol. 21, no. 3, p. 465-473
Abstract Hepatitis C virus (HCV) infection is a prevalent condition associated with numerous extrahepatic manifestations. Epidemiologic studies have found that HCV is associated with increased cardiovascular morbidity and mortality, in particular with carotid atherosclerosis, cerebrovascular events, and coronary heart disease. The mechanisms involved encompass a chronic systemic inflammatory state, insulin resistance, and a potential, direct infection of the vascular endothelium. Sustained virologic response with interferon-based regimens is associated with reduced cardiovascular events, although this must be validated with newer direct-acting antivirals. This clear association between HCV and cardiovascular events may have significant economical and public health implications.
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PMID: 28689586
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Article (Published version) (4.6 MB) - document accessible for UNIGE members only Limited access to UNIGE
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Research group Etudes et traitement de l'hépatite C et B (554)
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GOOSSENS, Nicolas, NEGRO, Francesco. Cardiovascular Manifestations of Hepatitis C Virus. In: Clinics in Liver Disease, 2017, vol. 21, n° 3, p. 465-473. https://archive-ouverte.unige.ch/unige:98372

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Deposited on : 2017-11-01

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