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Scientific article
English

Cardiovascular Manifestations of Hepatitis C Virus

Published inClinics in Liver Disease, vol. 21, no. 3, p. 465-473
Publication date2017
Abstract

Hepatitis C virus (HCV) infection is a prevalent condition associated with numerous extrahepatic manifestations. Epidemiologic studies have found that HCV is associated with increased cardiovascular morbidity and mortality, in particular with carotid atherosclerosis, cerebrovascular events, and coronary heart disease. The mechanisms involved encompass a chronic systemic inflammatory state, insulin resistance, and a potential, direct infection of the vascular endothelium. Sustained virologic response with interferon-based regimens is associated with reduced cardiovascular events, although this must be validated with newer direct-acting antivirals. This clear association between HCV and cardiovascular events may have significant economical and public health implications.

Citation (ISO format)
GOOSSENS, Nicolas, NEGRO, Francesco. Cardiovascular Manifestations of Hepatitis C Virus. In: Clinics in Liver Disease, 2017, vol. 21, n° 3, p. 465–473. doi: 10.1016/j.cld.2017.03.003
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ISSN of the journal1089-3261
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Creation09/14/2017 12:21:00 PM
First validation09/14/2017 12:21:00 PM
Update time03/15/2023 2:14:07 AM
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