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Flow Chronopotentiometry with Ion-Selective Membranes for Cation, Anion, and Polyion Detection

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Published in Analytical Chemistry. 2016, vol. 88, no. 7, p. 3945-3952
Abstract We report here on the development of a chronopotentiometric readout for ionselective electrodes that allows one to record transition times in continuous flow conditions without the necessity to stop the flow. A sample plug of 150 μL is injected into the carrier solution (0.5 mM NaCl) and subsequently transported to the detection cell (∼20 μL) at moderate flow rates (∼0.5 mL min−1), where a short current pulse (5s) is applied between the ionophore-based working electrode and a biocompatible and nonpolarizable Donnan exclusion anion-exchanger membrane reference/ counter electrode. Flow conditions bear an influence on the thickness of the aqueous diffusion layer and result in a shift of the chronopotentiometric transition time with respect to stopped flow. Two models based on rotating disk electrodes and flow chronopotentiometry at metal-based electrodes were used to corroborate the data. The method was successfully applied to the determination of calcium, chloride, alkalinity, acidity, and protamine with a range of ion-selective membranes. Because of the limiting exposure time of ca. 20 s of the membranes with the sample, this approach is demonstrated to be useful for the detection of protamine in the therapeutic range of undiluted human blood.
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Research group Groupe Bakker
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GHAHRAMAN AFSHAR, Majid, CRESPO PARAVANO, Gaston Adrian, BAKKER, Eric. Flow Chronopotentiometry with Ion-Selective Membranes for Cation, Anion, and Polyion Detection. In: Analytical Chemistry, 2016, vol. 88, n° 7, p. 3945-3952. https://archive-ouverte.unige.ch/unige:97901

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Deposited on : 2017-10-23

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