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Scientific article
English

Does the gravity orientation of saccular aneurysms influence hemodynamics? An experimental study with and without flow diverter stent

Contributors

Chodzyński, Kamil J.; Eker, Omer F.; Vanrossomme, Axel E.; Ribeiro de Sousa, Daniel; Coussement, Grégory; Vanhamme, Luc; Dubois, Frank; Bonafé, Alain; Chopard, Bastien; Courbebaisse, Guy; Zouaoui Boudjeltia, Karim

Published in

Journal of Biomechanics, vol. 49, no. 16, p. 3808-3814

Publication date

2016

Abstract

Most intracranial aneurysms morphologic studies focused on characterization of size, location, aspect ratio, relationship to the surrounding vasculature and hemodynamics. However, the spatial orientation with respect to the gravity direction has not been taken into account although it could trigger various hemodynamic conditions. The present work addresses this possibility. It was divided in two parts: 1) the orientations of 18, 3D time-of-flight MRI (3D TOF MRI), scans of saccular aneurysms were analyzed. This investigation suggested that there was no privileged orientation for cerebral aneurysms. The aneurysms were oriented in the brain as follows: 9 – down, 9 – up; 11 – right, 7 – left; 6 – front, 12 – back. 2) Based on these results, subsidiary in vitro experiments were performed, analyzing the behavior of red blood cells (RBCs) within a silicone model of aneurysm before and after flow diverter stent (FDS) deployment in the parent vessel. These experiments used a test bench that reproduces physiological pulsatile flow conditions for two orientations: an aneurysm sack pointing either up (opposite to gravitational force) and down (along the gravitational force). The results showed that the orientation of an aneurysm significantly affects the intra-aneurysmal RBCs behavior after stenting, and therefore that gravity can affect the intra-aneurysm behavior of RBCs. This suggests that the patient׳s aneurysm orientation could impact the outcome of the FDS treatment. The implementation of this effect in patient-specific numerical and preoperative decision support techniques could contribute to better understand the intrasaccular biological and hemodynamic events induced by FDS.

Keywords

  • Flow diverter stent
  • Red Blood Cells
  • In vitro test bench
  • Intracranial aneurysms
  • Gravity

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

CHODZYŃSKI, Kamil J. et al. Does the gravity orientation of saccular aneurysms influence hemodynamics? An experimental study with and without flow diverter stent. In: Journal of Biomechanics, 2016, vol. 49, n° 16, p. 3808–3814. doi: 10.1016/j.jbiomech.2016.10.007

Main files (1)

Article (Published version)

Identifiers

Additional URL for this publication

http://linkinghub.elsevier.com/retrieve/pii/S0021929016310880

Journal ISSN

0021-9290
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Technical informations

Creation

05/10/2017 13:02:00

First validation

05/10/2017 13:02:00

Update

15/03/2023 02:07:37

Status update

15/03/2023 02:07:36

Last indexation

31/10/2024 08:03:27
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