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Scientific article
Open access
English

Omission of doxorubicin from the treatment of stage II-III, intermediate-risk Wilms' tumour (SIOP WT 2001): an open-label, non-inferiority, randomised controlled trial

Published inThe Lancet, vol. 386, no. 9999, p. 1156-1164
Publication date2015
Abstract

Before this study started, the standard postoperative chemotherapy regimen for stage II-III Wilms' tumour pretreated with chemotherapy was to include doxorubicin. However, avoidance of doxorubicin-related cardiotoxicity effects is important to improve long-term outcomes for childhood cancers that have excellent prognosis. We aimed to assess whether doxorubicin can be omitted safely from chemotherapy for stage II-III, histological intermediate-risk Wilms' tumour when a newly defined high-risk blastemal subtype was excluded from randomisation.

Keywords
  • Adolescent
  • Antineoplastic Combined Chemotherapy Protocols/adverse effects/therapeutic use
  • Chemotherapy, Adjuvant/adverse effects/methods
  • Child
  • Child, Preschool
  • Dactinomycin/administration & dosage/adverse effects
  • Doxorubicin/administration & dosage/adverse effects
  • Female
  • Humans
  • Infant
  • Kaplan-Meier Estimate
  • Kidney Neoplasms/drug therapy/pathology/surgery
  • Male
  • Neoadjuvant Therapy/adverse effects/methods
  • Neoplasm Staging
  • Nephrectomy
  • Treatment Outcome
  • Vincristine/administration & dosage/adverse effects
  • Wilms Tumor/drug therapy/pathology/surgery
Citation (ISO format)
PRITCHARD-JONES, Kathy et al. Omission of doxorubicin from the treatment of stage II-III, intermediate-risk Wilms” tumour (SIOP WT 2001): an open-label, non-inferiority, randomised controlled trial. In: The Lancet, 2015, vol. 386, n° 9999, p. 1156–1164. doi: 10.1016/S0140-6736(14)62395-3
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Article (Published version)
Identifiers
ISSN of the journal0140-6736
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203downloads

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