UNIGE document Scientific Article
previous document  unige:97111  next document
add to browser collection
Title

Lactoferrin and prematurity: a promising milk protein?

Authors
Ochoa, Theresa J
Published in Biochemistry and Cell Biology. 2017, vol. 95, no. 1, p. 22-30
Abstract Lactoferrin (Lf) is the major whey protein in milk, with multiple beneficial health effects including direct antimicrobial activities, anti-inflammatory effects, and iron homeostasis. Oral Lf supplementation in human preterm infants has been shown to reduce the incidence of sepsis and necrotizing enterocolitis. In preclinical models of antenatal stress and perinatal brain injury, bovine Lf protected the developing brain from neuronal loss, improved connectivity, increased neurotrophic factors, and decreased inflammation. It also supported brain development and cognition. Further, Lf can prevent preterm delivery by reducing proinflammatory factors and inhibiting premature cervix maturation. We review here the latest research on Lf in the field of neonatology.
Keywords AnimalsAnti-Infective Agents/pharmacologyCattleHumansInfant, Premature/metabolismLactoferrin/pharmacology
Identifiers
PMID: 28085488
Full text
Article (Published version) (442 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research group L'imagerie cérébrale (184)
Citation
(ISO format)
OCHOA, Theresa J, SIZONENKO, Stéphane. Lactoferrin and prematurity: a promising milk protein?. In: Biochemistry and Cell Biology, 2017, vol. 95, n° 1, p. 22-30. https://archive-ouverte.unige.ch/unige:97111

71 hits

0 download

Update

Deposited on : 2017-09-27

Export document
Format :
Citation style :