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Scientific article
English

Lactoferrin and prematurity: a promising milk protein?

Contributors

Ochoa, Theresa J; Sizonenko, Stéphane

Published in

Biochemistry and Cell Biology, vol. 95, no. 1, p. 22-30

Publication date

2017

Abstract

Lactoferrin (Lf) is the major whey protein in milk, with multiple beneficial health effects including direct antimicrobial activities, anti-inflammatory effects, and iron homeostasis. Oral Lf supplementation in human preterm infants has been shown to reduce the incidence of sepsis and necrotizing enterocolitis. In preclinical models of antenatal stress and perinatal brain injury, bovine Lf protected the developing brain from neuronal loss, improved connectivity, increased neurotrophic factors, and decreased inflammation. It also supported brain development and cognition. Further, Lf can prevent preterm delivery by reducing proinflammatory factors and inhibiting premature cervix maturation. We review here the latest research on Lf in the field of neonatology.

Keywords

  • Animals
  • Anti-Infective Agents/pharmacology
  • Cattle
  • Humans
  • Infant, Premature/metabolism
  • Lactoferrin/pharmacology

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

OCHOA, Theresa J, SIZONENKO, Stéphane. Lactoferrin and prematurity: a promising milk protein? In: Biochemistry and Cell Biology, 2017, vol. 95, n° 1, p. 22–30. doi: 10.1139/bcb-2016-0066

Main files (1)

Article (Published version)

Identifiers

Journal ISSN

1208-6002
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Technical informations

Creation

27/09/2017 14:59:00

First validation

27/09/2017 14:59:00

Update

15/03/2023 02:04:06

Status update

15/03/2023 02:04:06

Last indexation

31/10/2024 07:54:05
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