Rare Genome-Wide Copy Number Variation and Expression of Schizophrenia in 22q11.2 Deletion Syndrome

International Chromosome 22q11.2 Consortium; Brain and Behavior Consortium

doi:10.1176/appi.ajp.2017.16121417

Scientific article

English

Rare Genome-Wide Copy Number Variation and Expression of Schizophrenia in 22q11.2 Deletion Syndrome

ContributorsInternational Chromosome 22q11.2 Consortium; Brain and Behavior Consortium

CollaboratorsEliez, Stéphan; Schneider, Maude

Published inAmerican Journal of Psychiatry, appiajp201716121417

Publication date2017

Abstract

Chromosome 22q11.2 deletion syndrome (22q11.2DS) is associated with a more than 20-fold increased risk for developing schizophrenia. The aim of this study was to identify additional genetic factors (i.e., "second hits") that may contribute to schizophrenia expression.

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de psychiatrie

Research groups

Laboratoire d'imagerie et de psychopathologie développementale (693)

Citation (ISO format)

International Chromosome 22q11.2 Consortium, Brain and Behavior Consortium. Rare Genome-Wide Copy Number Variation and Expression of Schizophrenia in 22q11.2 Deletion Syndrome. In: American Journal of Psychiatry, 2017, p. appiajp201716121417. doi: 10.1176/appi.ajp.2017.16121417

Article (Published version)

Identifiers

PID : unige:97041
DOI : 10.1176/appi.ajp.2017.16121417
PMID : 28750581

Journal ISSN0002-953X

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First validation21/09/2017 16:57:00

Update13/10/2025 19:46:44

Status update15/03/2023 02:03:22

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Rare Genome-Wide Copy Number Variation and Expression of Schizophrenia in 22q11.2 Deletion Syndrome

Chromosome 22q11.2 deletion syndrome (22q11.2DS) is associated with a more than 20-fold increased risk for developing schizophrenia. The aim of this study was to identify additional genetic factors (i.e., "second hits") that may contribute to schizophrenia expression.

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