Muscle-specific activation of Ca(2+)/calmodulin-dependent protein kinase IV increases whole-body insulin action in mice

Lee, Hui-Young; Gattu, Arijeet K; Camporez, João-Paulo G; Kanda, Shoichi; Guigni, Blas; Kahn, Mario; Zhang, Dongyan; Galbo, Thomas; Birkenfeld, Andreas L; Jornayvaz, François; Jurczak, Michael J; Choi, Cheol Soo; Yan, Zhen; Williams, R Sanders; Shulman, Gerald I; Samuel, Varman T

doi:10.1007/s00125-014-3212-1

Scientific article

English

Muscle-specific activation of Ca(2+)/calmodulin-dependent protein kinase IV increases whole-body insulin action in mice

Contributors

Lee, Hui-Young; Gattu, Arijeet K; Camporez, João-Paulo G; Kanda, Shoichi; Guigni, Blas; Kahn, Mario; Zhang, Dongyan; Galbo, Thomas; Birkenfeld, Andreas L; Jornayvaz, François

; Jurczak, Michael J; Choi, Cheol Soo; Yan, Zhen; Williams, R Sanders; Shulman, Gerald I; Samuel, Varman T

Published in

Diabetologia, vol. 57, no. 6, p. 1232-1241

Publication date

2014

Abstract

Aerobic exercise increases muscle glucose and improves insulin action through numerous pathways, including activation of Ca(2+)/calmodulin-dependent protein kinases (CAMKs) and peroxisome proliferator γ coactivator 1α (PGC-1α). While overexpression of PGC-1α increases muscle mitochondrial content and oxidative type I fibres, it does not improve insulin action. Activation of CAMK4 also increases the content of type I muscle fibres, PGC-1α level and mitochondrial content. However, it remains unknown whether CAMK4 activation improves insulin action on glucose metabolism in vivo.

Keywords

Animals
Calcium-Calmodulin-Dependent Protein Kinase Type 4/genetics/metabolism
Female
Glucose/metabolism
Insulin/metabolism
Male
Mice
Mitochondrial Proteins/genetics/metabolism
Muscle, Skeletal/enzymology
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
Transcription Factors/genetics

UNIGE affiliation entities

Not a UNIGE publication

Citation (ISO format)

LEE, Hui-Young et al. Muscle-specific activation of Ca(2+)/calmodulin-dependent protein kinase IV increases whole-body insulin action in mice. In: Diabetologia, 2014, vol. 57, n° 6, p. 1232–1241. doi: 10.1007/s00125-014-3212-1

Article (Published version)

Identifiers

PID : unige:96971
DOI : 10.1007/s00125-014-3212-1
PMID : 24718953

Journal ISSN

0012-186X

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13/09/2017 16:22:00

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Update

15/03/2023 02:02:48

Status update

15/03/2023 02:02:47

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31/10/2024 07:51:18

Muscle-specific activation of Ca(2+)/calmodulin-dependent protein kinase IV increases whole-body insulin action in mice

Contributors

Published in

Publication date

Abstract

Keywords

UNIGE affiliation entities

Citation (ISO format)

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Journal ISSN

Technical informations

Creation

First validation

Update

Status update

Last indexation