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Title

Muscle-specific activation of Ca(2+)/calmodulin-dependent protein kinase IV increases whole-body insulin action in mice

Authors
Lee, Hui-Young
Gattu, Arijeet K
Camporez, João-Paulo G
Kanda, Shoichi
Guigni, Blas
Kahn, Mario
Zhang, Dongyan
Galbo, Thomas
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Published in Diabetologia. 2014, vol. 57, no. 6, p. 1232-1241
Abstract Aerobic exercise increases muscle glucose and improves insulin action through numerous pathways, including activation of Ca(2+)/calmodulin-dependent protein kinases (CAMKs) and peroxisome proliferator γ coactivator 1α (PGC-1α). While overexpression of PGC-1α increases muscle mitochondrial content and oxidative type I fibres, it does not improve insulin action. Activation of CAMK4 also increases the content of type I muscle fibres, PGC-1α level and mitochondrial content. However, it remains unknown whether CAMK4 activation improves insulin action on glucose metabolism in vivo.
Keywords AnimalsCalcium-Calmodulin-Dependent Protein Kinase Type 4/genetics/metabolismFemaleGlucose/metabolismInsulin/metabolismMaleMiceMitochondrial Proteins/genetics/metabolismMuscle, Skeletal/enzymologyPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaTranscription Factors/genetics
Identifiers
PMID: 24718953
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LEE, Hui-Young et al. Muscle-specific activation of Ca(2+)/calmodulin-dependent protein kinase IV increases whole-body insulin action in mice. In: Diabetologia, 2014, vol. 57, n° 6, p. 1232-1241. https://archive-ouverte.unige.ch/unige:96971

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Deposited on : 2017-09-22

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