en
Scientific article
Open access
English

Hepatic insulin resistance and increased hepatic glucose production in mice lacking Fgf21

Published inJournal of Endocrinology, vol. 226, no. 3, p. 207-217
Publication date2015
Abstract

Fibroblast growth factor 21 (FGF21) is an important regulator of hepatic glucose and lipid metabolism and represents a potential pharmacological agent for the treatment of type 2 diabetes and obesity. Mice fed a ketogenic diet (KD) develop hepatic insulin resistance in association with high levels of FGF21, suggesting a state of FGF21 resistance. To address the role of FGF21 in hepatic insulin resistance, we assessed insulin action in FGF21 whole-body knock-out (FGF21 KO) male mice and their littermate WT controls fed a KD. Here, we report that FGF21 KO mice have hepatic insulin resistance and increased hepatic glucose production associated with an increase in plasma glucagon levels. FGF21 KO mice are also hypometabolic and display increased fat mass compared with their WT littermates. Taken together, these findings support a major role of FGF21 in regulating energy expenditure and hepatic glucose and lipid metabolism, and its potential role as a candidate in the treatment of diseases associated with insulin resistance.

Keywords
  • Animals
  • Blood Glucose/metabolism
  • Energy Metabolism/physiology
  • Fibroblast Growth Factors/genetics/metabolism
  • Glucagon/blood
  • Gluconeogenesis/physiology
  • Glucose/biosynthesis
  • Glycogen/metabolism
  • Insulin Resistance/genetics
  • Lipids/blood
  • Liver/metabolism
  • Male
  • Mice
  • Mice, Knockout
Affiliation Not a UNIGE publication
Citation (ISO format)
CAMPOREZ, João Paulo G et al. Hepatic insulin resistance and increased hepatic glucose production in mice lacking Fgf21. In: Journal of Endocrinology, 2015, vol. 226, n° 3, p. 207–217. doi: 10.1530/JOE-15-0136
Main files (1)
Article (Published version)
accessLevelPublic
Identifiers
ISSN of the journal0022-0795
634views
272downloads

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