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Title

Diabetes Mellitus Is Associated With Reduced High-Density Lipoprotein Sphingosine-1-Phosphate Content and Impaired High-Density Lipoprotein Cardiac Cell Protection

Authors
Prost, Jean-Christophe
Löfgren, Patrik
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Published in Arteriosclerosis, Thrombosis, and Vascular Biology. 2016, vol. 36, no. 5, p. 817-824
Abstract The dyslipidemia of type 2 diabetes mellitus has multiple etiologies and impairs lipoprotein functionality, thereby increasing risk for cardiovascular disease. High-density lipoproteins (HDLs) have several beneficial effects, notably protecting the heart from myocardial ischemia. We hypothesized that glycation of HDL could compromise this cardioprotective effect.
Keywords AnimalsAnimals, NewbornCase-Control StudiesCell SurvivalCells, CulturedDiabetes Mellitus, Type 2/blood/complications/diagnosisDiabetic Cardiomyopathies/blood/diagnosis/etiology/prevention & controlDyslipidemias/blood/diagnosis/etiologyGenotypeGlycosylationHemoglobin A, Glycosylated/metabolismHumansIsolated Heart PreparationLipoproteins, HDL/bloodLysophospholipids/bloodMaleMice, Inbred C57BLMice, KnockoutMyocardial Reperfusion Injury/metabolism/pathology/prevention & controlMyocytes, Cardiac/metabolism/pathologyOxidative StressPhenotypeRNA InterferenceRats, WistarScavenger Receptors, Class B/deficiency/genetics/metabolismSphingosine/analogs & derivatives/bloodTime FactorsTransfection
Identifiers
PMID: 26966278
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Research group L'athérosclérose (665)
Citation
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BRINCK, Jonas et al. Diabetes Mellitus Is Associated With Reduced High-Density Lipoprotein Sphingosine-1-Phosphate Content and Impaired High-Density Lipoprotein Cardiac Cell Protection. In: Arteriosclerosis, Thrombosis, and Vascular Biology, 2016, vol. 36, n° 5, p. 817-824. https://archive-ouverte.unige.ch/unige:96958

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Deposited on : 2017-09-22

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