Diabetes Mellitus Is Associated With Reduced High-Density Lipoprotein Sphingosine-1-Phosphate Content and Impaired High-Density Lipoprotein Cardiac Cell Protection

Brinck, Jonas; Thomas, Aurélien; Lauer, Estelle; Jornayvaz, François; Brulhart-Meynet, Marie-Claude; Prost, Jean-Christophe; Pataky, Zoltan; Löfgren, Patrik; Hoffstedt, Johan; Eriksson, Mats; Pramfalk, Camilla; Morel, Sandrine; Kwak, Brenda; van Eck, Miranda; James, Richard William; Frias, Miguel

doi:10.1161/ATVBAHA.115.307049

Article scientifique

Anglais

Diabetes Mellitus Is Associated With Reduced High-Density Lipoprotein Sphingosine-1-Phosphate Content and Impaired High-Density Lipoprotein Cardiac Cell Protection

Contributeurs/tricesBrinck, Jonas; Thomas, Aurélien; Lauer, Estelle; Jornayvaz, François; Brulhart-Meynet, Marie-Claude; Prost, Jean-Christophe; Pataky, Zoltan

; Löfgren, Patrik; Hoffstedt, Johan; Eriksson, Mats; Pramfalk, Camilla; Morel, Sandrine

; Kwak, Brenda; van Eck, Miranda; James, Richard William; Frias, Miguel

Publié dansArteriosclerosis, Thrombosis, and Vascular Biology, vol. 36, no. 5, p. 817-824

Date de publication2016

Résumé

The dyslipidemia of type 2 diabetes mellitus has multiple etiologies and impairs lipoprotein functionality, thereby increasing risk for cardiovascular disease. High-density lipoproteins (HDLs) have several beneficial effects, notably protecting the heart from myocardial ischemia. We hypothesized that glycation of HDL could compromise this cardioprotective effect.

Mots-clés

Animals
Animals, Newborn
Case-Control Studies
Cell Survival
Cells, Cultured
Diabetes Mellitus, Type 2/blood/complications/diagnosis
Diabetic Cardiomyopathies/blood/diagnosis/etiology/prevention & control
Dyslipidemias/blood/diagnosis/etiology
Genotype
Glycosylation
Hemoglobin A, Glycosylated/metabolism
Humans
Isolated Heart Preparation
Lipoproteins, HDL/blood
Lysophospholipids/blood
Male
Mice, Inbred C57BL
Mice, Knockout
Myocardial Reperfusion Injury/metabolism/pathology/prevention & control
Myocytes, Cardiac/metabolism/pathology
Oxidative Stress
Phenotype
RNA Interference
Rats, Wistar
Scavenger Receptors, Class B/deficiency/genetics/metabolism
Sphingosine/analogs & derivatives/blood
Time Factors
Transfection

Structure d'affiliation

Groupe de recherche

Citation (format ISO)

BRINCK, Jonas et al. Diabetes Mellitus Is Associated With Reduced High-Density Lipoprotein Sphingosine-1-Phosphate Content and Impaired High-Density Lipoprotein Cardiac Cell Protection. In: Arteriosclerosis, Thrombosis, and Vascular Biology, 2016, vol. 36, n° 5, p. 817–824. doi: 10.1161/ATVBAHA.115.307049

Article (Published version)

Identifiants

PID : unige:96958
DOI : 10.1161/ATVBAHA.115.307049
PMID : 26966278

ISSN du journal1079-5642

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Diabetes Mellitus Is Associated With Reduced High-Density Lipoprotein Sphingosine-1-Phosphate Content and Impaired High-Density Lipoprotein Cardiac Cell Protection

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