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Title

Characterization of a metabolomic profile associated with responsiveness to therapy in the acute phase of septic shock

Authors
Cambiaghi, Alice
Brunelli, Laura
Falcetta, Francesca
Aletti, Federico
Pastorelli, Roberta
Ferrario, Manuela
Published in Scientific Reports. 2017, vol. 7, no. 1, p. 9748
Abstract The early metabolic signatures associated with the progression of septic shock and with responsiveness to therapy can be useful for developing target therapy. The Sequential Organ Failure Assessment (SOFA) score is used for stratifying risk and predicting mortality. This study aimed to verify whether different responses to therapy, assessed as changes in SOFA score at admission (T1, acute phase) and 48 h later (T2, post-resuscitation), are associated with different metabolite patterns. We examined the plasma metabolome of 21 septic shock patients (pts) enrolled in the Shockomics clinical trial (NCT02141607). Patients for which SOFAT2 was >8 and Δ = SOFAT1 - SOFAT2 < 5, were classified as not responsive to therapy (NR, 7 pts), the remaining 14 as responsive (R). We combined untargeted and targeted mass spectrometry-based metabolomics strategies to cover the plasma metabolites repertoire as far as possible. Metabolite concentration changes from T1 to T2 (Δ = T2 - T1) were used to build classification models. Our results support the emerging evidence that lipidome alterations play an important role in individual patients' responses to infection. Furthermore, alanine indicates a possible alteration in the glucose-alanine cycle in the liver, providing a different picture of liver functionality from bilirubin. Understanding these metabolic disturbances is important for developing any effective tailored therapy for these patients.
Identifiers
PMID: 28851978
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Article (Published version) (2.2 MB) - public document Free access
Structures
Research group Groupe de recherche en hémodynamique (913)
Project FP7: SHOCKOMICS
Citation
(ISO format)
CAMBIAGHI, Alice et al. Characterization of a metabolomic profile associated with responsiveness to therapy in the acute phase of septic shock. In: Scientific Reports, 2017, vol. 7, n° 1, p. 9748. https://archive-ouverte.unige.ch/unige:96886

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Deposited on : 2017-09-20

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