Emerging role of epigenetics and miRNA in diabetic cardiomyopathy

Asrih, Mohamed; Steffens, Sabine

doi:10.1016/j.carpath.2012.07.004

Scientific article

English

Emerging role of epigenetics and miRNA in diabetic cardiomyopathy

Contributors

Asrih, Mohamed; Steffens, Sabine

Published in

Cardiovascular Pathology, vol. 22, no. 2, p. 117-125

Publication date

2013

Abstract

The prevalence of heart failure independent of coronary artery disease and hypertension is increasing rapidly in diabetic patients. Thus, this pathophysiology has been recognized as a distinct clinical entity termed "diabetic cardiomyopathy." Several studies support the notion that diabetes is a threatening insult for the myocardium resulting in functional, cellular, and structural changes manifesting as a cardiac myopathy. Recent data suggested that epigenetics including DNA and histone modifications as well as microRNAs play an important role in the development of cardiac diseases. The role of epigenetics in diabetes is largely recognized; however, its role in diabetes-associated cardiomyopathy remains elusive. Thus, molecular, cellular, and functional modulations in the diabetic cardiomyopathy will be investigated in this review. Moreover, particular attention will be drawn on the epigenetic mechanisms that may play an important role in the pathophysiology of diabetic cardiomyopathy.

Keywords

DNA Methylation
Diabetic Cardiomyopathies/genetics/pathology/physiopathology
Dyslipidemias/complications/metabolism
Epigenesis, Genetic
Histones/metabolism
Humans
Hyperglycemia/complications/metabolism
MicroRNAs/genetics
Models, Cardiovascular
Oxidative Stress
Protein Kinase C/metabolism
Sarcoplasmic Reticulum Calcium-Transporting ATPases/metabolism

UNIGE affiliation entities

Faculté de médecine / Section de médecine clinique / Département des neurosciences cliniques

UNIGE research groups

Ophtalmologie expérimentale (925)

Citation (ISO format)

ASRIH, Mohamed, STEFFENS, Sabine. Emerging role of epigenetics and miRNA in diabetic cardiomyopathy. In: Cardiovascular Pathology, 2013, vol. 22, n° 2, p. 117–125. doi: 10.1016/j.carpath.2012.07.004

Article (Published version)

Identifiers

PID : unige:96810
DOI : 10.1016/j.carpath.2012.07.004
PMID : 22951386

Journal ISSN

1054-8807

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28/07/2017 09:38:00

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28/07/2017 09:38:00

Update

15/03/2023 02:01:12

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15/03/2023 02:01:12

Last indexation

31/10/2024 07:46:43

Emerging role of epigenetics and miRNA in diabetic cardiomyopathy

Contributors

Published in

Publication date

Abstract

Keywords

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

Main files (1)

Identifiers

Journal ISSN

Technical informations

Creation

First validation

Update

Status update

Last indexation