Scientific article
English

Bosentan as Adjunctive Therapy for Persistent Pulmonary Hypertension of the Newborn: Results of the Randomized Multicenter Placebo-Controlled Exploratory Trial

Published inThe Journal of Pediatrics, vol. 177, p. 90-96.e3
Publication date2016
Abstract

To evaluate the efficacy, safety, and pharmacokinetics of the endothelin receptor antagonist bosentan as adjunctive therapy for neonates with persistent pulmonary hypertension of the newborn (PPHN).

Keywords
  • Double-Blind Method
  • Endothelin Receptor Antagonists/adverse effects/therapeutic use
  • Female
  • Humans
  • Infant
  • Newborn
  • Male
  • Nitric Oxide/administration & dosage
  • Persistent Fetal Circulation Syndrome/drug therapy
  • Respiration
  • Artificial
  • Sulfonamides/adverse effects/therapeutic use
  • Treatment Failure
  • Treatment Outcome
Citation (ISO format)
STEINHORN, Robin H et al. Bosentan as Adjunctive Therapy for Persistent Pulmonary Hypertension of the Newborn: Results of the Randomized Multicenter Placebo-Controlled Exploratory Trial. In: The Journal of Pediatrics, 2016, vol. 177, p. 90–96.e3. doi: 10.1016/j.jpeds.2016.06.078
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
Journal ISSN0022-3476
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Technical informations

Creation14/09/2017 14:01:00
First validation14/09/2017 14:01:00
Update time15/03/2023 02:00:19
Status update15/03/2023 02:00:19
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