UNIGE document Scientific Article
previous document  unige:96555  next document
add to browser collection
Title

Association of busulfan exposure with survival and toxicity after haemopoietic cell transplantation in children and young adults: a multicentre, retrospective cohort analysis

Authors
Bartelink, Imke H
Lalmohamed, Arief
van Reij, Elisabeth M L
Dvorak, Christopher C
Savic, Rada M
Zwaveling, Juliette
Bredius, Robbert G M
Egberts, Antoine C G
show hidden authors show all authors [1 - 32]
Published in The Lancet. Haematology. 2016, vol. 3, no. 11, p. e526-e536
Abstract Intravenous busulfan combined with therapeutic drug monitoring to guide dosing improves outcomes after allogeneic haemopoietic cell transplantation (HCT). The best method to estimate busulfan exposure and optimum exposure in children or young adults remains unclear. We therefore assessed three approaches to estimate intravenous busulfan exposure (expressed as cumulative area under the curve [AUC]) and associated busulfan AUC with clinical outcomes in children or young adults undergoing allogeneic HCT.
Identifiers
PMID: 27746112
Full text
Article (Published version) (596 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Article (Author postprint) (1 MB) - public document Free access
Structures
Research group Plateforme d'oncologie et d'hématologie pédiatrique (907)
Citation
(ISO format)
BARTELINK, Imke H et al. Association of busulfan exposure with survival and toxicity after haemopoietic cell transplantation in children and young adults: a multicentre, retrospective cohort analysis. In: The Lancet. Haematology, 2016, vol. 3, n° 11, p. e526-e536. https://archive-ouverte.unige.ch/unige:96555

72 hits

24 downloads

Update

Deposited on : 2017-09-08

Export document
Format :
Citation style :