Association of busulfan exposure with survival and toxicity after haemopoietic cell transplantation in children and young adults: a multicentre, retrospective cohort analysis

Bartelink, Imke H; Lalmohamed, Arief; van Reij, Elisabeth M L; Dvorak, Christopher C; Savic, Rada M; Zwaveling, Juliette; Bredius, Robbert G M; Egberts, Antoine C G; Bierings, Marc; Kletzel, Morris; Shaw, Peter J; Nath, Christa E; Hempel, George; Ansari Djaberi, Marc Georges; Krajinovic, Maja; Théorêt, Yves; Duval, Michel; Keizer, Ron J; Bittencourt, Henrique; Hassan, Moustapha; Güngör, Tayfun; Wynn, Robert F; Veys, Paul; Cuvelier, Geoff D E; Marktel, Sarah; Chiesa, Robert; Cowan, Morton J; Slatter, Mary A; Stricherz, Melisa K; Jennissen, Cathryn; Long-Boyle, Janel R; Boelens, Jaap Jan

doi:10.1016/S2352-3026(16)30114-4

Scientific article

English

Association of busulfan exposure with survival and toxicity after haemopoietic cell transplantation in children and young adults: a multicentre, retrospective cohort analysis

Published inThe Lancet. Haematology, vol. 3, no. 11, p. e526-e536

Publication date2016

Abstract

Intravenous busulfan combined with therapeutic drug monitoring to guide dosing improves outcomes after allogeneic haemopoietic cell transplantation (HCT). The best method to estimate busulfan exposure and optimum exposure in children or young adults remains unclear. We therefore assessed three approaches to estimate intravenous busulfan exposure (expressed as cumulative area under the curve [AUC]) and associated busulfan AUC with clinical outcomes in children or young adults undergoing allogeneic HCT.

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique

Research groups

Oncologie et hématologie pédiatrique (907)

Citation (ISO format)

BARTELINK, Imke H et al. Association of busulfan exposure with survival and toxicity after haemopoietic cell transplantation in children and young adults: a multicentre, retrospective cohort analysis. In: The Lancet. Haematology, 2016, vol. 3, n° 11, p. e526–e536. doi: 10.1016/S2352-3026(16)30114-4