Epidermal growth factor receptor overexpression is common and not correlated to gene copy number in ependymoma

Friedrich, Carsten; Von Bueren, André; Kolevatova, Larissa; Bernreuther, Christian; Grob, Tobias; Sepulveda-Falla, Diego; van den Boom, Leander; Westphal, Manfred; Simon, Ronald; Glatzel, Markus

doi:10.1007/s00381-015-2981-2

Scientific article

English

Epidermal growth factor receptor overexpression is common and not correlated to gene copy number in ependymoma

ContributorsFriedrich, Carsten; Von Bueren, André

; Kolevatova, Larissa; Bernreuther, Christian; Grob, Tobias; Sepulveda-Falla, Diego; van den Boom, Leander; Westphal, Manfred; Simon, Ronald; Glatzel, Markus

Published inChild's Nervous System, vol. 32, no. 2, p. 281-290

Publication date2016

Abstract

The aim of this study was to investigate the epidermal growth factor receptor (EGFR) status in ependymoma specimens, as there is a need for new prognostic and druggable targets in this disease.

Keywords

Adolescent
Adult
Aged
Brain Neoplasms/genetics
Child
Child, Preschool
Ependymoma/genetics
Female
Gene Dosage/genetics
Humans
Immunohistochemistry
In Situ Hybridization, Fluorescence
Infratentorial Neoplasms/genetics
Male
Middle Aged
Mutation
Receptor, Epidermal Growth Factor/genetics
Spinal Cord Neoplasms/genetics
Supratentorial Neoplasms/genetics
Tissue Array Analysis
Young Adult

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique

Research groups

Oncologie et hématologie pédiatriques (907)

Citation (ISO format)

FRIEDRICH, Carsten et al. Epidermal growth factor receptor overexpression is common and not correlated to gene copy number in ependymoma. In: Child’s Nervous System, 2016, vol. 32, n° 2, p. 281–290. doi: 10.1007/s00381-015-2981-2

Article (Published version)

Identifiers

PID : unige:96549
DOI : 10.1007/s00381-015-2981-2
PMID : 26686534

Journal ISSN0256-7040

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Epidermal growth factor receptor overexpression is common and not correlated to gene copy number in ependymoma

The aim of this study was to investigate the epidermal growth factor receptor (EGFR) status in ependymoma specimens, as there is a need for new prognostic and druggable targets in this disease.

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