UNIGE document Scientific Article
previous document  unige:96509  next document
add to browser collection

Vaccination in early life: standing up to the challenges

Published in Current opinion in immunology. 2016, vol. 41, p. 1-8
Abstract The challenge for any vaccine design is to elicit protective humoral and/or cytotoxic immunity against life threatening pathogens while remaining innocuous. Neonatal vaccinology faces additional challenges linked to intrinsic peculiarities of the innate and adaptive neonatal immune system. These include anti-inflammatory rather than pro-inflammatory responses to innate signals, preferential Th2 differentiation limiting the induction of Th1 and cytotoxic responses, trends to immunoregulatory responses and weak plasma cell and germinal centre B cell responses. Recent progresses in our understanding of the molecular bases of these physiological peculiarities and of the mode of action of novel adjuvants open new opportunities to design vaccine formulations and immunization strategies better adapted to the early life period.
PMID: 27104290
Full text
Article (Published version) (1.1 MB) - document accessible for UNIGE members only Limited access to UNIGE
Research group Centre de vaccinologie et d'immunologie néonatale (177)
(ISO format)
MOHR, Elodie, SIEGRIST, Claire-Anne. Vaccination in early life: standing up to the challenges. In: Current Opinion in Immunology, 2016, vol. 41, p. 1-8. doi: 10.1016/j.coi.2016.04.004 https://archive-ouverte.unige.ch/unige:96509

371 hits

1 download


Deposited on : 2017-09-06

Export document
Format :
Citation style :