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Cytotoxic flavonoids and other constituents from the stem bark of Ochna schweinfurthiana

Ndongo, Joseph T
Messi, Angelique N
Mbing, Joséphine Ngo
Pegnyemb, Dieudonné E
Bochet, Christian G
Published in Natural Product Research. 2015, vol. 29, no. 17, p. 1684-7
Abstract Seven flavonoids, hemerocallone (1), 6,7-dimethoxy-3',4'-dimethoxyisoflavone (2), amentoflavone (4), agathisflavone (6), cupressuflavone (8), robustaflavone (9) and epicatechin (10), together with three other compounds, lithospermoside (3), β-D-fructofuranosyl-α-D-glucopyranoside (5) and 3β-O-D-glucopyranosyl-β-stigmasterol (7), were isolated from the ethyl acetate extract of the stem bark of Ochna schweinfurthiana F. Hoffm. All the compounds were characterised by spectroscopic and mass spectrometric methods, and by comparison with literature data. Cytotoxicity of the extracts and compounds against cervical adenocarcinoma (HeLa) cells was evaluated by MTT assay. Compounds 4 and 6 exhibited good cytotoxic activity, with IC50 values of 20.7 and 10.0 μM, respectively.
Keywords Biflavonoids/chemistryFlavonoids/chemistryHeLa CellsHumansInhibitory Concentration 50Molecular StructureOchnaceae/chemistryPlant Bark/chemistryPlant Extracts/chemistry
PMID: 25553908
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NDONGO, Joseph T et al. Cytotoxic flavonoids and other constituents from the stem bark of Ochna schweinfurthiana. In: Natural Product Research, 2015, vol. 29, n° 17, p. 1684-7. doi: 10.1080/14786419.2014.991321 https://archive-ouverte.unige.ch/unige:94984

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Deposited on : 2017-06-20

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