en
Scientific article
English

Cytotoxic flavonoids and other constituents from the stem bark of Ochna schweinfurthiana

Published inNatural product research, vol. 29, no. 17, p. 1684-1687
Publication date2015
Abstract

Seven flavonoids, hemerocallone (1), 6,7-dimethoxy-3',4'-dimethoxyisoflavone (2), amentoflavone (4), agathisflavone (6), cupressuflavone (8), robustaflavone (9) and epicatechin (10), together with three other compounds, lithospermoside (3), β-D-fructofuranosyl-α-D-glucopyranoside (5) and 3β-O-D-glucopyranosyl-β-stigmasterol (7), were isolated from the ethyl acetate extract of the stem bark of Ochna schweinfurthiana F. Hoffm. All the compounds were characterised by spectroscopic and mass spectrometric methods, and by comparison with literature data. Cytotoxicity of the extracts and compounds against cervical adenocarcinoma (HeLa) cells was evaluated by MTT assay. Compounds 4 and 6 exhibited good cytotoxic activity, with IC50 values of 20.7 and 10.0 μM, respectively.

Keywords
  • Biflavonoids/chemistry
  • Flavonoids/chemistry
  • HeLa Cells
  • Humans
  • Inhibitory Concentration 50
  • Molecular Structure
  • Ochnaceae/chemistry
  • Plant Bark/chemistry
  • Plant Extracts/chemistry
Citation (ISO format)
NDONGO, Joseph T et al. Cytotoxic flavonoids and other constituents from the stem bark of Ochna schweinfurthiana. In: Natural product research, 2015, vol. 29, n° 17, p. 1684–1687. doi: 10.1080/14786419.2014.991321
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal1478-6419
327views
0downloads

Technical informations

Creation06/13/2017 8:03:00 PM
First validation06/13/2017 8:03:00 PM
Update time03/15/2023 1:47:37 AM
Status update03/15/2023 1:47:37 AM
Last indexation05/02/2024 7:23:32 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack