Scientific article

Cytotoxic flavonoids and other constituents from the stem bark of Ochna schweinfurthiana

Published inNatural product research, vol. 29, no. 17, p. 1684-1687
Publication date2015

Seven flavonoids, hemerocallone (1), 6,7-dimethoxy-3',4'-dimethoxyisoflavone (2), amentoflavone (4), agathisflavone (6), cupressuflavone (8), robustaflavone (9) and epicatechin (10), together with three other compounds, lithospermoside (3), β-D-fructofuranosyl-α-D-glucopyranoside (5) and 3β-O-D-glucopyranosyl-β-stigmasterol (7), were isolated from the ethyl acetate extract of the stem bark of Ochna schweinfurthiana F. Hoffm. All the compounds were characterised by spectroscopic and mass spectrometric methods, and by comparison with literature data. Cytotoxicity of the extracts and compounds against cervical adenocarcinoma (HeLa) cells was evaluated by MTT assay. Compounds 4 and 6 exhibited good cytotoxic activity, with IC50 values of 20.7 and 10.0 μM, respectively.

  • Biflavonoids/chemistry
  • Flavonoids/chemistry
  • HeLa Cells
  • Humans
  • Inhibitory Concentration 50
  • Molecular Structure
  • Ochnaceae/chemistry
  • Plant Bark/chemistry
  • Plant Extracts/chemistry
Citation (ISO format)
NDONGO, Joseph T et al. Cytotoxic flavonoids and other constituents from the stem bark of Ochna schweinfurthiana. In: Natural product research, 2015, vol. 29, n° 17, p. 1684–1687. doi: 10.1080/14786419.2014.991321
Main files (1)
Article (Published version)
ISSN of the journal1478-6419

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