en
Scientific article
English

Investigation on the ZBG-functionality of phenyl-4-yl-acrylohydroxamic acid derivatives as histone deacetylase inhibitors

Published inBioorganic & medicinal chemistry letters, vol. 25, no. 20, p. 4457-4460
Publication date2015
Abstract

A series of alternative Zn-binding groups were explored in the design of phenyl-4-yl-acrylohydroxamic acid derivatives as histone deacetylase (HDAC) inhibitors. Most of the synthesized compounds were less effective than the parent hydroxamic acid. However, the profile of activity shown by the analog bearing a hydroxyurea head group, makes this derivative promising for further investigation.

Keywords
  • Cell Line
  • Tumor
  • Cell Proliferation/drug effects
  • Dose-Response Relationship
  • Drug
  • Histone Deacetylase 2/antagonists & inhibitors/metabolism
  • Histone Deacetylase Inhibitors/chemical synthesis/chemistry/pharmacology
  • Humans
  • Hydroxamic Acids/chemistry/pharmacology
  • Models
  • Molecular
  • Molecular Structure
  • Organometallic Compounds/chemical synthesis/chemistry/pharmacology
  • Structure-Activity Relationship
  • Zinc/chemistry/pharmacology
Citation (ISO format)
MUSSO, Loana et al. Investigation on the ZBG-functionality of phenyl-4-yl-acrylohydroxamic acid derivatives as histone deacetylase inhibitors. In: Bioorganic & medicinal chemistry letters, 2015, vol. 25, n° 20, p. 4457–4460. doi: 10.1016/j.bmcl.2015.09.006
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal0960-894X
437views
0downloads

Technical informations

Creation13.06.2017 21:31:00
First validation13.06.2017 21:31:00
Update time15.03.2023 01:47:35
Status update15.03.2023 01:47:34
Last indexation17.01.2024 00:11:19
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack