Synthesis of an Uncharged Tetra-cyclopeptide Acting as a Transmembrane Carrier: Enhanced Cellular and Nuclear Uptake

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Title		Synthesis of an Uncharged Tetra-cyclopeptide Acting as a Transmembrane Carrier: Enhanced Cellular and Nuclear Uptake
Authors		Francisco Hilário, Flaviane Traoré, Mohamed Dit Mady Zwick, Vincent Berry, Laurence Simoes Avello, Claudia Cuendet, Muriel Fantozzi, Nicolas Pereira de Freitas, Rossimiriam Maynadier, Marjorie Wein, Sharon Vial, Henri Wong, Yung-Sing show all authors [1 - 12]
Published in		Organic letters. 2017, vol. 19, no. 3, p. 612-615
Abstract		A small uncharged cyclopeptide scaffold inspired by a natural product and designed to undergo postfunctionalizations was used as a new transmembrane vector. A bioactive and fluorescent triazole aminocoumarin was bound to this carrier to facilitate its moving across cell and subcellular membranes, and this led to an increase in its cell toxicity.
Identifiers		DOI: 10.1021/acs.orglett.6b03776 PMID: 28107021
Full text		Article (Published version) (1.4 MB) - Limited access to UNIGE
Structures		Faculté des sciences / Section des sciences pharmaceutiques
Citation (ISO format)		FRANCISCO HILÁRIO, Flaviane et al. Synthesis of an Uncharged Tetra-cyclopeptide Acting as a Transmembrane Carrier: Enhanced Cellular and Nuclear Uptake. In: Organic letters, 2017, vol. 19, n° 3, p. 612-615. doi: 10.1021/acs.orglett.6b03776 https://archive-ouverte.unige.ch/unige:94968