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Synthesis of an Uncharged Tetra-cyclopeptide Acting as a Transmembrane Carrier: Enhanced Cellular and Nuclear Uptake |
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Published in | Organic letters. 2017, vol. 19, no. 3, p. 612-615 | |
Abstract | A small uncharged cyclopeptide scaffold inspired by a natural product and designed to undergo postfunctionalizations was used as a new transmembrane vector. A bioactive and fluorescent triazole aminocoumarin was bound to this carrier to facilitate its moving across cell and subcellular membranes, and this led to an increase in its cell toxicity. | |
Identifiers | PMID: 28107021 | |
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Citation (ISO format) | FRANCISCO HILÁRIO, Flaviane et al. Synthesis of an Uncharged Tetra-cyclopeptide Acting as a Transmembrane Carrier: Enhanced Cellular and Nuclear Uptake. In: Organic letters, 2017, vol. 19, n° 3, p. 612-615. doi: 10.1021/acs.orglett.6b03776 https://archive-ouverte.unige.ch/unige:94968 |