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Scientific article
English

Synthesis of an Uncharged Tetra-cyclopeptide Acting as a Transmembrane Carrier: Enhanced Cellular and Nuclear Uptake

Published inOrganic letters, vol. 19, no. 3, p. 612-615
Publication date2017
Abstract

A small uncharged cyclopeptide scaffold inspired by a natural product and designed to undergo postfunctionalizations was used as a new transmembrane vector. A bioactive and fluorescent triazole aminocoumarin was bound to this carrier to facilitate its moving across cell and subcellular membranes, and this led to an increase in its cell toxicity.

Citation (ISO format)
FRANCISCO HILÁRIO, Flaviane et al. Synthesis of an Uncharged Tetra-cyclopeptide Acting as a Transmembrane Carrier: Enhanced Cellular and Nuclear Uptake. In: Organic letters, 2017, vol. 19, n° 3, p. 612–615. doi: 10.1021/acs.orglett.6b03776
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ISSN of the journal1523-7052
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Creation06/14/2017 9:50:00 AM
First validation06/14/2017 9:50:00 AM
Update time03/15/2023 1:47:27 AM
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