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Title

Synthesis of an Uncharged Tetra-cyclopeptide Acting as a Transmembrane Carrier: Enhanced Cellular and Nuclear Uptake

Authors
Francisco Hilário, Flaviane
Traoré, Mohamed Dit Mady
Berry, Laurence
Fantozzi, Nicolas
Pereira de Freitas, Rossimiriam
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Published in Organic Letters. 2017, vol. 19, no. 3, p. 612-615
Abstract A small uncharged cyclopeptide scaffold inspired by a natural product and designed to undergo postfunctionalizations was used as a new transmembrane vector. A bioactive and fluorescent triazole aminocoumarin was bound to this carrier to facilitate its moving across cell and subcellular membranes, and this led to an increase in its cell toxicity.
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PMID: 28107021
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FRANCISCO HILÁRIO, Flaviane et al. Synthesis of an Uncharged Tetra-cyclopeptide Acting as a Transmembrane Carrier: Enhanced Cellular and Nuclear Uptake. In: Organic Letters, 2017, vol. 19, n° 3, p. 612-615. https://archive-ouverte.unige.ch/unige:94968

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Deposited on : 2017-06-20

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