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Scientific article
English

Superacid and thiol-ene reactions for access to psammaplin analogues with HDAC inhibition activities

Published inTetrahedron, vol. 70, no. 51, p. 9702-9708
Publication date2014
Abstract

An innovative synthesis of psammaplin-like structure is proposed based on original methodologies using superacid, microwaves, and S-ene chemistry. The new compounds were evaluated as histone deacetylase inhibitors. The results highlight important considerations when using disulfide prodrugs activated under reductive/oxidative conditions that must be carefully selected depending on tumor cell types.

Citation (ISO format)
EL BAHHAJ, Fatima et al. Superacid and thiol-ene reactions for access to psammaplin analogues with HDAC inhibition activities. In: Tetrahedron, 2014, vol. 70, n° 51, p. 9702–9708. doi: 10.1016/j.tet.2014.10.053
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ISSN of the journal0040-4020
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