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Superacid and thiol-ene reactions for access to psammaplin analogues with HDAC inhibition activities

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El Bahhaj, Fatima
Désiré, Jérôme
Blanquart, Christophe
Martinet, Nadine
Grégoire, Marc
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Published in Tetrahedron. 2014, vol. 70, no. 51, p. 9702-9708
Abstract An innovative synthesis of psammaplin-like structure is proposed based on original methodologies using superacid, microwaves, and S-ene chemistry. The new compounds were evaluated as histone deacetylase inhibitors. The results highlight important considerations when using disulfide prodrugs activated under reductive/oxidative conditions that must be carefully selected depending on tumor cell types.
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EL BAHHAJ, Fatima et al. Superacid and thiol-ene reactions for access to psammaplin analogues with HDAC inhibition activities. In: Tetrahedron, 2014, vol. 70, n° 51, p. 9702-9708. https://archive-ouverte.unige.ch/unige:94962

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Deposited on : 2017-06-20

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