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Recommendations for CSF AD biomarkers in the diagnostic evaluation of dementia

Simonsen, Anja Hviid
Herukka, Sanna-Kaisa
Andreasen, Niels
Baldeiras, Ines
Bjerke, Maria
Blennow, Kaj
Engelborghs, Sebastiaan
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Published in Alzheimer's & dementia. 2017, vol. 13, no. 3, p. 274-284
Abstract This article presents recommendations, based on the Grading of Recommendations, Assessment, Development, and Evaluation method, for the clinical application of cerebrospinal fluid (CSF) amyloid-β1-42, tau, and phosphorylated tau in the diagnostic evaluation of patients with dementia. The recommendations were developed by a multidisciplinary working group based on the available evidence and consensus from focused discussions for (i) identification of Alzheimer's disease (AD) as the cause of dementia, (ii) prediction of rate of decline, (iii) cost-effectiveness, and (iv) interpretation of results. The working group found sufficient evidence to support a recommendation to use CSF AD biomarkers as a supplement to clinical evaluation, particularly in uncertain and atypical cases, to identify or exclude AD as the cause of dementia. Because of insufficient evidence, it was uncertain whether CSF AD biomarkers outperform imaging biomarkers. Operational recommendations for the interpretation of ambiguous CSF biomarker results were also provided.
PMID: 28341065
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Research group Troubles de mémoire et maladie d'Alzeimer (935)
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SIMONSEN, Anja Hviid et al. Recommendations for CSF AD biomarkers in the diagnostic evaluation of dementia. In: Alzheimer's & dementia, 2017, vol. 13, n° 3, p. 274-284. doi: 10.1016/j.jalz.2016.09.008 https://archive-ouverte.unige.ch/unige:94827

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Deposited on : 2017-06-13

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