The frequency and influence of dementia risk factors in prodromal Alzheimer&#039;s disease

Bos, Isabelle; Vos, Stephanie J; Frölich, Lutz; Kornhuber, Johannes; Wiltfang, Jens; Maier, Wolfgang; Peters, Oliver; Rüther, Eckhart; Engelborghs, Sebastiaan; Niemantsverdriet, Ellis; De Roeck, Ellen Elisa; Tsolaki, Magda; Freund-Levi, Yvonne; Johannsen, Peter; Vandenberghe, Rik; Lleó, Alberto; Alcolea, Daniel; Frisoni, Giovanni; Galluzzi, Samantha; Nobili, Flavio; Morbelli, Silvia; Drzezga, Alexander; Didic, Mira; van Berckel, Bart N; Salmon, Eric; Bastin, Christine; Dauby, Solene; Santana, Isabel; Baldeiras, Inês; de Mendonça, Alexandre; Silva, Dina; Wallin, Anders; Nordlund, Arto; Coloma, Preciosa M; Wientzek, Angelika; Alexander, Myriam; Novak, Gerald P; Gordon, Mark Forrest; Wallin, Åsa K; Hampel, Harald; Soininen, Hilkka; Herukka, Sanna-Kaisa; Scheltens, Philip; Verhey, Frans R

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Title		The frequency and influence of dementia risk factors in prodromal Alzheimer's disease
Authors		Bos, Isabelle Vos, Stephanie J Frölich, Lutz Kornhuber, Johannes Wiltfang, Jens Maier, Wolfgang Peters, Oliver Rüther, Eckhart Engelborghs, Sebastiaan Niemantsverdriet, Ellis De Roeck, Ellen Elisa Tsolaki, Magda Freund-Levi, Yvonne Johannsen, Peter Vandenberghe, Rik Lleó, Alberto Alcolea, Daniel Frisoni, Giovanni Galluzzi, Samantha Nobili, Flavio Morbelli, Silvia Drzezga, Alexander Didic, Mira van Berckel, Bart N Salmon, Eric Bastin, Christine Dauby, Solene Santana, Isabel Baldeiras, Inês de Mendonça, Alexandre Silva, Dina Wallin, Anders Nordlund, Arto Coloma, Preciosa M Wientzek, Angelika Alexander, Myriam Novak, Gerald P Gordon, Mark Forrest Wallin, Åsa K Hampel, Harald Soininen, Hilkka Herukka, Sanna-Kaisa Scheltens, Philip Verhey, Frans R show all authors [1 - 44]
Published in		Neurobiology of Aging. 2017, vol. 56, p. 33-40
Abstract		We investigated whether dementia risk factors were associated with prodromal Alzheimer's disease (AD) according to the International Working Group-2 and National Institute of Aging-Alzheimer's Association criteria, and with cognitive decline. A total of 1394 subjects with mild cognitive impairment from 14 different studies were classified according to these research criteria, based on cognitive performance and biomarkers. We compared the frequency of 10 risk factors between the subgroups, and used Cox-regression to examine the effect of risk factors on cognitive decline. Depression, obesity, and hypercholesterolemia occurred more often in individuals with low-AD-likelihood, compared with those with a high-AD-likelihood. Only alcohol use increased the risk of cognitive decline, regardless of AD pathology. These results suggest that traditional risk factors for AD are not associated with prodromal AD or with progression to dementia, among subjects with mild cognitive impairment. Future studies should validate these findings and determine whether risk factors might be of influence at an earlier stage (i.e., preclinical) of AD.
Identifiers		DOI: 10.1016/j.neurobiolaging.2017.03.034 PMID: 28482212
Full text		Article (Published version) (317 Kb) - Limited access to UNIGE
Structures		Faculté de médecine / Section de médecine clinique / Département de psychiatrie
Research group		Troubles de mémoire et maladie d'Alzeimer (935)
Citation (ISO format)		BOS, Isabelle et al. The frequency and influence of dementia risk factors in prodromal Alzheimer's disease. In: Neurobiology of Aging, 2017, vol. 56, p. 33-40. https://archive-ouverte.unige.ch/unige:94819