Scientific article

The frequency and influence of dementia risk factors in prodromal Alzheimer's disease

Published inNeurobiology of aging, vol. 56, p. 33-40
Publication date2017

We investigated whether dementia risk factors were associated with prodromal Alzheimer's disease (AD) according to the International Working Group-2 and National Institute of Aging-Alzheimer's Association criteria, and with cognitive decline. A total of 1394 subjects with mild cognitive impairment from 14 different studies were classified according to these research criteria, based on cognitive performance and biomarkers. We compared the frequency of 10 risk factors between the subgroups, and used Cox-regression to examine the effect of risk factors on cognitive decline. Depression, obesity, and hypercholesterolemia occurred more often in individuals with low-AD-likelihood, compared with those with a high-AD-likelihood. Only alcohol use increased the risk of cognitive decline, regardless of AD pathology. These results suggest that traditional risk factors for AD are not associated with prodromal AD or with progression to dementia, among subjects with mild cognitive impairment. Future studies should validate these findings and determine whether risk factors might be of influence at an earlier stage (i.e., preclinical) of AD.

Citation (ISO format)
BOS, Isabelle, FRISONI, Giovanni. The frequency and influence of dementia risk factors in prodromal Alzheimer’s disease. In: Neurobiology of aging, 2017, vol. 56, p. 33–40. doi: 10.1016/j.neurobiolaging.2017.03.034
Main files (1)
Article (Published version)
ISSN of the journal0197-4580

Technical informations

Creation06/08/2017 11:16:00 AM
First validation06/08/2017 11:16:00 AM
Update time03/15/2023 1:46:00 AM
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