Association between CSF biomarkers, hippocampal volume and cognitive function in patients with amnestic mild cognitive impairment (MCI)

Nathan, Pradeep J; Lim, Yen Ying; Abbott, Rosemary; Galluzzi, Samantha; Marizzoni, Moira; Babiloni, Claudio; Albani, Diego; Bartres-Faz, David; Didic, Mira; Farotti, Lucia; Parnetti, Lucilla; Salvadori, Nicola; Müller, Bernhard W; Forloni, Gianluigi; Girtler, Nicola; Hensch, Tilman; Jovicich, Jorge; Leeuwis, Annebet; Marra, Camillo; Molinuevo, José Luis; Nobili, Flavio; Pariente, Jeremie; Payoux, Pierre; Ranjeva, Jean-Philippe; Rolandi, Elena; Rossini, Paolo Maria; Schönknecht, Peter; Soricelli, Andrea; Tsolaki, Magda; Visser, Pieter Jelle; Wiltfang, Jens; Richardson, Jill C; Bordet, Régis; Blin, Olivier; Frisoni, Giovanni

doi:10.1016/j.neurobiolaging.2017.01.013

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Title		Association between CSF biomarkers, hippocampal volume and cognitive function in patients with amnestic mild cognitive impairment (MCI)
Authors		Nathan, Pradeep J Lim, Yen Ying Abbott, Rosemary Galluzzi, Samantha Marizzoni, Moira Babiloni, Claudio Albani, Diego Bartres-Faz, David Didic, Mira Farotti, Lucia Parnetti, Lucilla Salvadori, Nicola Müller, Bernhard W Forloni, Gianluigi Girtler, Nicola Hensch, Tilman Jovicich, Jorge Leeuwis, Annebet Marra, Camillo Molinuevo, José Luis Nobili, Flavio Pariente, Jeremie Payoux, Pierre Ranjeva, Jean-Philippe Rolandi, Elena Rossini, Paolo Maria Schönknecht, Peter Soricelli, Andrea Tsolaki, Magda Visser, Pieter Jelle Wiltfang, Jens Richardson, Jill C Bordet, Régis Blin, Olivier Frisoni, Giovanni show all authors [1 - 35]
Published in		Neurobiology of Aging. 2017, vol. 53, p. 1-10
Abstract		Few studies have examined the relationship between CSF and structural biomarkers, and cognitive function in MCI. We examined the relationship between cognitive function, hippocampal volume and cerebrospinal fluid (CSF) Aβ42 and tau in 145 patients with MCI. Patients were assessed on cognitive tasks from the Cambridge Neuropsychological Test Automated Battery (CANTAB), the Geriatric Depression Scale and the Functional Activities Questionnaire. Hippocampal volume was measured using magnetic resonance imaging (MRI), and CSF markers of Aβ42, tau and p-tau181 were also measured. Worse performance on a wide range of memory and sustained attention tasks were associated with reduced hippocampal volume, higher CSF tau and p-tau181 and increased tau/Aβ42 ratio. Memory tasks were also associated with lower ability to conduct functional activities of daily living, providing a link between AD biomarkers, memory performance and functional outcome. These results suggest that biomarkers of Aβ and tau are strongly related to cognitive performance as assessed by the CANTAB, and have implications for the early detection and characterization of incipient AD.
Identifiers		DOI: 10.1016/j.neurobiolaging.2017.01.013 PMID: 28189924
Full text		Article (Published version) (1.2 MB) - Limited access to UNIGE
Structures		Faculté de médecine / Section de médecine clinique / Département de psychiatrie
Research group		Troubles de mémoire et maladie d'Alzeimer (935)
Citation (ISO format)		NATHAN, Pradeep J et al. Association between CSF biomarkers, hippocampal volume and cognitive function in patients with amnestic mild cognitive impairment (MCI). In: Neurobiology of Aging, 2017, vol. 53, p. 1-10. doi: 10.1016/j.neurobiolaging.2017.01.013 https://archive-ouverte.unige.ch/unige:94818