Deficient phagocytosis secondary to breakdown of opsonic factors in infected exudates

Waldvogel, Francis; Vaudaux, Pierre; Lew, Daniel Pablo; Zwahlen, A.; Suter, S.; Nydegger, U.

doi:10.1007/978-1-4684-8088-7_59

Scientific article

English

Deficient phagocytosis secondary to breakdown of opsonic factors in infected exudates

Contributors

Waldvogel, Francis; Vaudaux, Pierre; Lew, Daniel Pablo; Zwahlen, A.; Suter, S.; Nydegger, U.

Published in

Advances in experimental medicine and biology, vol. 141, p. 603-610

Publication date

1982

Abstract

Pleural empyema, a clinical entity characterized by the simultaneous presence of large number of PMNLs and viable bacteria, is a biological paradox which has not been fully explained yet. Our preliminary studies suggest that receptor and bactericidal functions of PMNL isolated from purulent exudates, can be close to normal in this condition. Supernatants of these empyemas however have been shown to be low in heat labile opsonic activity and complement hemolytic activity. These observations have been extended by the demonstration of breakdown of IgG, C3 and factor B in infected pleural effusions as opposed to pleural fluids obtained under other conditions. The breakdown of Ig and C3 seems to be enzymatic and to occur, at least for C3, even in the absence of Ca and Mg ions: thus, direct cleavage of C3, possibly by PMNL enzymes, has to be postulated to explain these results. Present work in our laboratory is trying to explore this possibility.

Keywords

Abscess/physiopathology
Blood Bactericidal Activity
Complement Activation
Empyema/ physiopathology
Exudates and Transudates/physiology
Humans
Neutrophils/physiology
Opsonin Proteins/ physiology
Phagocytosis

UNIGE affiliation entities

Faculté de médecine / Section de médecine fondamentale / Département de médecine génétique et développement

Citation (ISO format)

WALDVOGEL, Francis et al. Deficient phagocytosis secondary to breakdown of opsonic factors in infected exudates. In: Advances in experimental medicine and biology, 1982, vol. 141, p. 603–610. doi: 10.1007/978-1-4684-8088-7_59

Identifiers

PID : unige:9480
DOI : 10.1007/978-1-4684-8088-7_59
PMID : 7090931

Journal ISSN

0065-2598

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Deficient phagocytosis secondary to breakdown of opsonic factors in infected exudates

Contributors

Published in

Publication date

Abstract

Keywords

UNIGE affiliation entities

Citation (ISO format)

Identifiers

Journal ISSN

Technical informations

Creation

First validation

Update

Status update

Last indexation