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Aqueous humor penetration of ofloxacin given by various routes

von Gunten, S.
Paccolat, F.
Brazitikos, P. D.
Leuenberger, P. M.
Published in American Journal of Ophthalmology. 1994, vol. 117, no. 1, p. 87-89
Abstract We studied the aqueous humor penetration of ofloxacin after topical, oral, and intravenous administration in 51 consecutive patients undergoing cataract surgery. Aqueous humor concentration (mean +/- SD) was 0.53 +/- 0.35 mg/l when ofloxacin 0.3% eyedrops were instilled topically six times, one drop every three hours, until 90 minutes preoperatively, and 0.63 +/- 0.29 mg/l (P =.45) when two additional instillations were made, one drop every 30 minutes, until 30 minutes before aqueous humor aspiration. Aqueous humor concentration two hours after a single 200-mg oral dose (0.38 +/- 0.15 mg/l) was significantly lower (P =.048) than that 12 hours after the same oral dose (0.58 +/- 0.24 mg/l). Two hours following an intravenous infusion of 200 mg of ofloxacin, aqueous humor concentration was 0.33 +/- 0.19 mg/l. Our results suggest that therapeutic levels above the minimum inhibitory concentration for many bacteria cultured in endophthalmitis can be achieved in aqueous humor after either topical or oral administration, which indicates that this antibiotic passes easily through the corneal and the blood aqueous barriers.
Keywords Administration, OralAdministration, TopicalAgedAged, 80 and overAqueous Humor/ metabolismBiological AvailabilityCornea/metabolismDrug Administration RoutesFemaleHumansInfusions, IntravenousMaleMicrobial Sensitivity TestsMiddle AgedOfloxacin/administration & dosage/ pharmacokineticsOphthalmic SolutionsRandom Allocation
PMID: 8291598
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VON GUNTEN, S. et al. Aqueous humor penetration of ofloxacin given by various routes. In: American Journal of Ophthalmology, 1994, vol. 117, n° 1, p. 87-89. https://archive-ouverte.unige.ch/unige:9479

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