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Imaging of dopamine receptors with [123I]iodobenzamide single-photon emission-computed tomography in neuroleptic malignant syndrome

Jauss, M
Franz, M
Klett, R
Bauer, R
Gallhofer, B
Dorndorf, W
Published in Movement disorders. 1996, vol. 11, no. 6, p. 726-8
Abstract With the tracer [123I]iodobenzamide ([123I]-IBZM), it is possible to image dopamine receptor occupancy with single-photon emission-computed tomography (SPECT). We report follow-up examinations with IBZM-SPECT in neuroleptic malignant syndrome (NMS) to display D2-receptor availability in the acute phase and during the course of remission. A 27-year-old man was admitted with severe akinesia, rigor, tachycardia, fever, and elevated creatine phosphokinase level (CK) after neuroleptic medication. NMS was diagnosed, and treatment was started with dantrolene, amantadine, and dopamine agonists. IBZM-SPECT examination was performed on days 6, 34, 90, 107, 131, and 201. In the acute state of NMS, there was no binding of IBZM to D2-receptors. SPECT reached almost normal values on day 131, but clinical examination still showed a mild parkinsonian syndrome. With SPECT, the D2-receptor occupancy in NMS could be successfully shown in correlation with extrapyramidal signs. IBZM-SPECT may therefore serve to monitor D2-receptor occupancy in patients at risk for NMS.
Keywords AdultAntipsychotic Agents/adverse effects/therapeutic useBasal Ganglia/diagnostic imaging/drug effectsBenperidol/adverse effects/therapeutic useBenzamidesDopamine AntagonistsFrontal Lobe/diagnostic imaging/drug effectsHaloperidol/adverse effects/therapeutic useHumansIodine RadioisotopesMaleNeuroleptic Malignant Syndrome/diagnostic imaging/physiopathologyNeurologic Examination/drug effectsPsychotic Disorders/diagnostic imaging/drug therapyPyrrolidinesReceptors, Dopamine D2/drug effects/physiologyTomography, Emission-Computed, Single-Photon
PMID: 8914102
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JAUSS, M et al. Imaging of dopamine receptors with [123I]iodobenzamide single-photon emission-computed tomography in neuroleptic malignant syndrome. In: Movement disorders, 1996, vol. 11, n° 6, p. 726-8. doi: 10.1002/mds.870110621

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