Scientific article

Inhibition of levodopa effects by internal pallidal stimulation

Published inMovement disorders, vol. 13, no. 4, p. 648-652
Publication date1998

We report three patients with bilateral GPi stimulation for stage 4 Parkinson's disease (PD) with severe levodopa-induced dyskinesias (LID). In all three it was possible to completely inhibit LID using high-stimulation parameters. Parallel to complete inhibition of LID, an inhibition of the anti-akinetic effect of levodopa was observed, whereas, at the same time, rigidity was markedly improved. GPi stimulation is adaptable over time, and stimulation parameters have to be programmed according to off- and on-period motor symptoms. The main interest of stimulation is the possibility of finding a compromise between LID alleviation in on-phase without loss of the beneficial motor effects and improvement in parkinsonism in off-phase. In some patients, residual dyskinesias have to be accepted so as not to aggravate on-period motor symptoms by a presumed overinhibition of basal ganglia outflow.

  • Antiparkinson Agents/administration & dosage/adverse effects
  • Combined Modality Therapy
  • Dominance, Cerebral/drug effects/physiology
  • Dyskinesia, Drug-Induced/diagnosis/physiopathology/therapy
  • Electric Stimulation Therapy
  • Electrodes, Implanted
  • Globus Pallidus/drug effects/physiopathology
  • Humans
  • Levodopa/administration & dosage/adverse effects
  • Male
  • Middle Aged
  • Parkinson Disease/physiopathology/therapy
Affiliation Not a UNIGE publication
Citation (ISO format)
KRACK, Paul et al. Inhibition of levodopa effects by internal pallidal stimulation. In: Movement disorders, 1998, vol. 13, n° 4, p. 648–652. doi: 10.1002/mds.870130407
Main files (1)
Article (Published version)
ISSN of the journal0885-3185

Technical informations

Creation04/18/2017 11:37:00 AM
First validation04/18/2017 11:37:00 AM
Update time03/15/2023 1:44:43 AM
Status update03/15/2023 1:44:43 AM
Last indexation08/30/2023 2:52:47 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack