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Scientific Article
unige:94634 
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Electrical stimulation of the subthalamic nucleus in advanced Parkinson's disease |
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| Authors | ||
| Published in | New England Journal of Medicine. 1998, vol. 339, no. 16, p. 1105-11 | |
| Abstract | In many patients with idiopathic Parkinson's disease, treatment with levodopa is complicated by fluctuations between an "off" period, when the medication is not working and the motor symptoms of parkinsonism are present, and an "on" period, when the medication is causing improved mobility, often accompanied by debilitating dyskinesias. In animal models of Parkinson's disease, there is overactivity in the subthalamic nucleus, and electrical stimulation of the subthalamic nucleus improves parkinsonism. We therefore sought to determine the efficacy and safety of electrical stimulation of the subthalamic nucleus in patients with Parkinson's disease. | |
| Keywords | Activities of Daily Living — Antiparkinson Agents/therapeutic use — Combined Modality Therapy — Dyskinesia, Drug-Induced/etiology — Electric Stimulation Therapy — Electrodes, Implanted — Female — Follow-Up Studies — Humans — Levodopa/therapeutic use — Male — Middle Aged — Parkinson Disease/classification/drug therapy/therapy — Severity of Illness Index — Thalamic Nuclei | |
| Identifiers | PMID: 9770557 | |
| Full text | ||
| Citation (ISO format) | LIMOUSIN, P et al. Electrical stimulation of the subthalamic nucleus in advanced Parkinson's disease. In: New England Journal of Medicine, 1998, vol. 339, n° 16, p. 1105-11. doi: 10.1056/NEJM199810153391603 https://archive-ouverte.unige.ch/unige:94634 |
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