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Title

Electrical stimulation of the subthalamic nucleus in advanced Parkinson's disease

Authors
Limousin, P
Benazzouz, A
Ardouin, C
Hoffmann, D
Benabid, A L
Published in New England Journal of Medicine. 1998, vol. 339, no. 16, p. 1105-11
Abstract In many patients with idiopathic Parkinson's disease, treatment with levodopa is complicated by fluctuations between an "off" period, when the medication is not working and the motor symptoms of parkinsonism are present, and an "on" period, when the medication is causing improved mobility, often accompanied by debilitating dyskinesias. In animal models of Parkinson's disease, there is overactivity in the subthalamic nucleus, and electrical stimulation of the subthalamic nucleus improves parkinsonism. We therefore sought to determine the efficacy and safety of electrical stimulation of the subthalamic nucleus in patients with Parkinson's disease.
Keywords Activities of Daily LivingAntiparkinson Agents/therapeutic useCombined Modality TherapyDyskinesia, Drug-Induced/etiologyElectric Stimulation TherapyElectrodes, ImplantedFemaleFollow-Up StudiesHumansLevodopa/therapeutic useMaleMiddle AgedParkinson Disease/classification/drug therapy/therapySeverity of Illness IndexThalamic Nuclei
Identifiers
PMID: 9770557
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LIMOUSIN, P et al. Electrical stimulation of the subthalamic nucleus in advanced Parkinson's disease. In: New England Journal of Medicine, 1998, vol. 339, n° 16, p. 1105-11. https://archive-ouverte.unige.ch/unige:94634

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Deposited on : 2017-06-02

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