en
Scientific article
English

Electrical stimulation of the subthalamic nucleus in advanced Parkinson's disease

Published inThe New England journal of medicine, vol. 339, no. 16, p. 1105-1111
Publication date1998
Abstract

In many patients with idiopathic Parkinson's disease, treatment with levodopa is complicated by fluctuations between an "off" period, when the medication is not working and the motor symptoms of parkinsonism are present, and an "on" period, when the medication is causing improved mobility, often accompanied by debilitating dyskinesias. In animal models of Parkinson's disease, there is overactivity in the subthalamic nucleus, and electrical stimulation of the subthalamic nucleus improves parkinsonism. We therefore sought to determine the efficacy and safety of electrical stimulation of the subthalamic nucleus in patients with Parkinson's disease.

Keywords
  • Activities of Daily Living
  • Antiparkinson Agents/therapeutic use
  • Combined Modality Therapy
  • Dyskinesia, Drug-Induced/etiology
  • Electric Stimulation Therapy
  • Electrodes, Implanted
  • Female
  • Follow-Up Studies
  • Humans
  • Levodopa/therapeutic use
  • Male
  • Middle Aged
  • Parkinson Disease/classification/drug therapy/therapy
  • Severity of Illness Index
  • Thalamic Nuclei
Affiliation Not a UNIGE publication
Citation (ISO format)
LIMOUSIN, P et al. Electrical stimulation of the subthalamic nucleus in advanced Parkinson’s disease. In: The New England journal of medicine, 1998, vol. 339, n° 16, p. 1105–1111. doi: 10.1056/NEJM199810153391603
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Article (Published version)
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Identifiers
ISSN of the journal0028-4793
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