Scientific article

Treatment of tremor in Parkinson's disease by subthalamic nucleus stimulation

Published inMovement disorders, vol. 13, no. 6, p. 907-914
Publication date1998

The recent resurgent interest in functional surgery for the treatment of Parkinson's disease (PD) has focused on the effects on akinesia and levodopa-induced dyskinesia. Stimulation of the subthalamic nucleus (STN) improves akinesia and rigidity but its effects on tremor have not been studied. The objective of this study was to assess the efficacy of STN stimulation on tremor in patients with the complete parkinsonian triad with motor fluctuations. Of 27 consecutive patients with STN stimulation (26 bilateral), 15 exhibited tremor rated at least 2/4 according to item 20 (rest tremor) of the Unified Parkinson's Disease Rating Scale (UPDRS) in at least one limb. The mean preoperative tremor score was 11.3+/-5.6 in off-drug and 1.2+/-2.4 in on-drug conditions. The postoperative tremor scores at the last follow up (from 1-12 months) were 2.2+/-2.2 off-drug/on-stimulation and 0.2+/-0.4 on-drug/on-stimulation. Both rest and action tremors were improved in all patients. The UPDRS tremor score was reduced by 80%, rigidity score by 65%, and akinesia score by 51% on average. For the three symptoms, the stimulation effect was close to that induced before surgery by a suprathreshold dose of levodopa given in the morning. STN stimulation can be considered an interesting alternative to thalamic or internal pallidal surgery even in PD patients with severe high-amplitude tremor. In keeping with electrophysiological data in monkeys rendered parkinsonian by MPTP injections, our results emphasize the importance of the oscillation of a neuronal loop involving the STN in the pathophysiology of parkinsonian tremor.

  • Adult
  • Aged
  • Electric Stimulation Therapy
  • Electrodes, Implanted
  • Electrophysiology
  • Female
  • Humans
  • Male
  • Middle Aged
  • Parkinson Disease/therapy
  • Statistics, Nonparametric
  • Stereotaxic Techniques
  • Thalamic Nuclei
  • Tremor/therapy
Affiliation Not a UNIGE publication
Citation (ISO format)
KRACK, Paul et al. Treatment of tremor in Parkinson’s disease by subthalamic nucleus stimulation. In: Movement disorders, 1998, vol. 13, n° 6, p. 907–914. doi: 10.1002/mds.870130608
Main files (1)
Article (Published version)
ISSN of the journal0885-3185

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