UNIGE document Scientific Article
previous document  unige:94623  next document
add to browser collection
Title

Mesenteric inflammatory veno-occlusive disease of the spleen metasynchronous with two arterial thrombotic events in systemic lupus erythematosus

Authors
Published in Lupus. 2017, p. 961203317700980
Abstract Vasculitides, particularly those affecting small vessels, are known to complicate systemic lupus erythematosus (SLE); however, isolated venulitis of the mesenteric bed has rarely been reported. Here we relate the case of a 46-year-old woman with SLE who presented with acute abdominal pain due to artery thrombosis and extended splenic ischemia requiring splenectomy. The histological examination revealed diffuse venulitis in the absence of arterial vasculitis consistent with the definition of mesenteric inflammatory veno-occlusive disease (MIVOD). Furthermore, arterial wall thickening suggestive of uncomplicated atherosclerosis was observed. Two months later, the patient suffered of severe myocardial infarction (MI) resulting from thrombosis of the anterior interventricular coronary artery with otherwise no signs of coronary disease at coronarography. Extensive work-up to establish the cause of MI was negative, with the exception of marginal, isolated and transient elevation of cardiolipin IgG (14.5 GPL, n.v. 0-5 GPL). This patient's SLE history is dramatically marked by the previously non-described association of MIVOD and two arterial thrombotic events (splenic and coronary) occurring within a two months period, and stresses the need of better understanding and prevention of vascular complications in SLE.
Identifiers
PMID: 28355983
Full text
Article (Published version) (440 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research group La matrice extracellulaire (651)
Citation
(ISO format)
ALLALI, Danièle, PUPPA, Giacomo, CHIZZOLINI, Carlo. Mesenteric inflammatory veno-occlusive disease of the spleen metasynchronous with two arterial thrombotic events in systemic lupus erythematosus. In: Lupus, 2017, p. 961203317700980. https://archive-ouverte.unige.ch/unige:94623

16 hits

1 download

Update

Deposited on : 2017-06-02

Export document
Format :
Citation style :