How antipsychotics work: linking receptors to response

Ginovart, Nathalie; Kapur, Shitij

doi:10.1093/acprof:oso/9780195373035.003.0038

Book chapter

English

How antipsychotics work: linking receptors to response

Contributors

Ginovart, Nathalie

; Kapur, Shitij

Published in

Iversen, L., Iversen, S., Dunnet, S., Bjorklund, A. (Ed.), Dopamine Handbook, p. 640

Publisher

Oxford : Oxford University Press

Publication date

2009

Abstract

Schizophrenia is a chronic and disabling disease that typically begins during adolescence or early adult life and severely impacts psychosocial functioning. There is no known single cause of schizophrenia. It is hypothesized that genetic factors and early neurodevelopmental abnormalities (including apoptosis, disruption of neuronal migration, or alteration of synaptogenesis) may confer a constitutional vulnerability to the disease. Subsequent environmental factors (including obstetric complications, exposure to viral infection in utero, or exposure to psychosocial stress during childhood) may then trigger the behavioral expression of this vulnerability, perhaps via subtle alterations of brain development. Within this framework, dysregulations of the dopamine (DA) and glutamate neurotransmitter systems have been most intimately associated with the physiopathology of schizophrenia. This chapter focuses on this aspect of the illness, with special attention given to the DA receptors.

Keywords

Schizophrenia, dopamine, receptors, antipsychotic drugs

UNIGE affiliation entities

Faculté de médecine / Section de médecine clinique / Département de psychiatrie

UNIGE research groups

Imagerie de la transmission dopaminergique dans les troubles addictifs (989)

Citation (ISO format)

GINOVART, Nathalie, KAPUR, Shitij. How antipsychotics work: linking receptors to response. In: Dopamine Handbook. Iversen, L., Iversen, S., Dunnet, S., Bjorklund, A. (Ed.). Oxford : Oxford University Press, 2009. p. 640. doi: 10.1093/acprof:oso/9780195373035.003.0038

Identifiers

PID : unige:94604
DOI : 10.1093/acprof:oso/9780195373035.003.0038

ISBN

978-0-19-537303-5

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Creation

16/03/2017 14:55:00

First validation

16/03/2017 14:55:00

Update

15/03/2023 01:44:25

Status update

15/03/2023 01:44:25

Last indexation

31/10/2024 07:04:21

How antipsychotics work: linking receptors to response

Contributors

Published in

Publisher

Publication date

Abstract

Keywords

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

Identifiers

ISBN

Technical informations

Creation

First validation

Update

Status update

Last indexation