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Scientific article
Open access
English

Epidural analgesia in critically ill patients with acute pancreatitis: the multicentre randomised controlled EPIPAN study protocol

Published inBMJ open, vol. 7, no. 5, e015280
Publication date2017
Abstract

Acute pancreatitis (AP) is associated with high morbidity and mortality in its most severe forms. Most patients with severe AP require intubation and invasive mechanical ventilation, frequently for more than 7 days, which is associated with the worst outcome. Recent increasing evidence from preclinical and clinical studies support the beneficial effects of epidural analgesia (EA) in AP, such as increased gut barrier function and splanchnic, pancreatic and renal perfusion, decreased liver damage and inflammatory response, and reduced mortality. Because recent studies suggest that EA might be a safe procedure in the critically ill, we sought to determine whether EA reduced AP-associated respiratory failure and other major clinical outcomes in patients with AP.

Keywords
  • Acute pancreatitis
  • Epidural analgesia
  • Intensive care unit
  • Randomised controlled trial
Citation (ISO format)
BULYEZ, Stéphanie et al. Epidural analgesia in critically ill patients with acute pancreatitis: the multicentre randomised controlled EPIPAN study protocol. In: BMJ open, 2017, vol. 7, n° 5, p. e015280. doi: 10.1136/bmjopen-2016-015280
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Article (Published version)
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ISSN of the journal2044-6055
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Technical informations

Creation01.06.2017 13:40:00
First validation01.06.2017 13:40:00
Update time15.03.2023 01:44:22
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