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Title

Epidural analgesia in critically ill patients with acute pancreatitis: the multicentre randomised controlled EPIPAN study protocol

Authors
Bulyez, Stéphanie
Caumon, Elodie
Imhoff, Etienne
Roszyk, Laurence
Bernard, Lise
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Published in BMJ Open. 2017, vol. 7, no. 5, p. e015280
Abstract Acute pancreatitis (AP) is associated with high morbidity and mortality in its most severe forms. Most patients with severe AP require intubation and invasive mechanical ventilation, frequently for more than 7 days, which is associated with the worst outcome. Recent increasing evidence from preclinical and clinical studies support the beneficial effects of epidural analgesia (EA) in AP, such as increased gut barrier function and splanchnic, pancreatic and renal perfusion, decreased liver damage and inflammatory response, and reduced mortality. Because recent studies suggest that EA might be a safe procedure in the critically ill, we sought to determine whether EA reduced AP-associated respiratory failure and other major clinical outcomes in patients with AP.
Keywords Acute pancreatitisEpidural analgesiaIntensive care unitRandomised controlled trial
Identifiers
PMID: 28554928
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Article (Published version) (594 Kb) - public document Free access
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Research group Chirurgie viscérale (104)
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BULYEZ, Stéphanie et al. Epidural analgesia in critically ill patients with acute pancreatitis: the multicentre randomised controlled EPIPAN study protocol. In: BMJ Open, 2017, vol. 7, n° 5, p. e015280. https://archive-ouverte.unige.ch/unige:94597

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Deposited on : 2017-06-01

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