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Understanding key features of bacterial restriction-modification systems through quantitative modeling

Rodic, Andjela
Blagojevic, Bojana
Djordjevic, Magdalena
Djordjevic, Marko
Published in BMC Systems Biology. 2017, vol. 11, no. Suppl 1, p. 377
Abstract Restriction-modification (R-M) systems are rudimentary bacterial immune systems. The main components include restriction enzyme (R), which cuts specific unmethylated DNA sequences, and the methyltransferase (M), which protects the same DNA sequences. The expression of R-M system components is considered to be tightly regulated, to ensure successful establishment in a naïve bacterial host. R-M systems are organized in different architectures (convergent or divergent) and are characterized by different features, i.e. binding cooperativities, dissociation constants of dimerization, translation rates, which ensure this tight regulation. It has been proposed that R-M systems should exhibit certain dynamical properties during the system establishment, such as: i) a delayed expression of R with respect to M, ii) fast transition of R from "OFF" to "ON" state, iii) increased stability of the toxic molecule (R) steady-state levels. It is however unclear how different R-M system features and architectures ensure these dynamical properties, particularly since it is hard to address this question experimentally.
PMID: 28466789
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Research group Génomique Evolutionnaire Computationnelle (830)
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RODIC, Andjela et al. Understanding key features of bacterial restriction-modification systems through quantitative modeling. In: BMC Systems Biology, 2017, vol. 11, n° Suppl 1, p. 377. https://archive-ouverte.unige.ch/unige:94545

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Deposited on : 2017-05-30

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