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Title

Comparative efficacies of imipenem, oxacillin and vancomycin for therapy of chronic foreign body infection due to methicillin-susceptible and -resistant Staphylococcus aureus

Authors
Schaad, H. J.
Chuard, C.
Published in Journal of Antimicrobial Chemotherapy. 1994, vol. 33, no. 6, p. 1191-1200
Abstract The efficacies of imipenem when directed against methicillin-susceptible (MSSA) and methicillin-resistant (MRSA) strains of Staphylococcus aureus were compared with those of oxacillin and vancomycin in a subcutaneous rat model, using chronically infected tissue cages. At three weeks after inoculation, stable chronic infections were established with average bacterial counts exceeding 10(6) cfu/mL tissue cage fluid for both strains. Intraperitoneal administration (twice a day for 7 days) of imipenem (80 mg/kg) or oxacillin (200 mg/kg) produced peak levels of 23 or 45 mg/L and through levels of < 0.1 and 5.7 mg/L, respectively. The therapeutic regimens of either imipenem (P < 0.001) or oxacillin (P < 0.02) administered for 7 days led to significant reductions in bacterial counts in the tissue cage fluids of animals chronically infected with MSSA. In contrast, imipenem was not effective against chronic MRSA tissue cage infections, despite the relatively low MIC of the infecting strain and the use of high dose (120 mg/kg) therapy. In-vitro susceptibility testings of MRSA performed before and after imipenem therapy demonstrated the emergence of a highly resistant subpopulation.
Keywords AnimalsChronic DiseaseDiffusion Chambers, CultureDose-Response Relationship, DrugForeign-Body Reaction/ drug therapy/ microbiologyImipenem/ pharmacologyMethicillin ResistanceMicrobial Sensitivity TestsOxacillin/ pharmacologyPolytetrafluoroethyleneProstheses and ImplantsRatsRats, WistarStaphylococcal Infections/ drug therapy/microbiologyStaphylococcus aureus/ drug effectsVancomycin/ pharmacology
Identifiers
PMID: 7928812
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SCHAAD, H. J. et al. Comparative efficacies of imipenem, oxacillin and vancomycin for therapy of chronic foreign body infection due to methicillin-susceptible and -resistant Staphylococcus aureus. In: Journal of Antimicrobial Chemotherapy, 1994, vol. 33, n° 6, p. 1191-1200. https://archive-ouverte.unige.ch/unige:9453

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Deposited on : 2010-07-12

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