en
Scientific article
English

Quantification and Potential Functions of Endogenous Agonists of Transient Receptor Potential Channels in Patients With Irritable Bowel Syndrome

Published inGastroenterology, vol. 149, no. 2, p. 433-444.e7
Publication date2015
Abstract

In mice, activation of the transient receptor potential cation channels (TRP) TRPV1, TRPV4, and TRPA1 causes visceral hypersensitivity. These receptors and their agonists might be involved in development of irritable bowel syndrome (IBS). We investigated whether polyunsaturated fatty acid (PUFA) metabolites, which activate TRPs, are present in colon tissues from patients with IBS and act as endogenous agonists to induce hypersensitivity.

Keywords
  • Adult
  • Aged
  • Animals
  • Biopsy
  • Calcium Channels/metabolism
  • Chromatography, Liquid
  • Colon/cytology/innervation/metabolism
  • Dinoprostone/metabolism
  • Fatty Acids, Unsaturated/metabolism
  • Female
  • Ganglia, Spinal/cytology/metabolism
  • Humans
  • Irritable Bowel Syndrome/metabolism
  • Italy
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Middle Aged
  • Nerve Tissue Proteins/metabolism
  • RNA, Small Interfering/genetics
  • Sensory Receptor Cells/cytology/metabolism
  • Signal Transduction
  • TRPV Cation Channels/metabolism
  • Tandem Mass Spectrometry
  • Transient Receptor Potential Channels/metabolism
  • Young Adult
Affiliation Not a UNIGE publication
Citation (ISO format)
CENAC, Nicolas et al. Quantification and Potential Functions of Endogenous Agonists of Transient Receptor Potential Channels in Patients With Irritable Bowel Syndrome. In: Gastroenterology, 2015, vol. 149, n° 2, p. 433–444.e7. doi: 10.1053/j.gastro.2015.04.011
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal0016-5085
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