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Title

Quantification and Potential Functions of Endogenous Agonists of Transient Receptor Potential Channels in Patients With Irritable Bowel Syndrome

Authors
Cenac, Nicolas
Le Faouder, Pauline
Veldhuis, Nicholas A
Poole, Daniel P
Rolland, Corinne
Bertrand, Jessica
Liedtke, Wolfgang
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Published in Gastroenterology. 2015, vol. 149, no. 2, p. 433-44.e7
Abstract In mice, activation of the transient receptor potential cation channels (TRP) TRPV1, TRPV4, and TRPA1 causes visceral hypersensitivity. These receptors and their agonists might be involved in development of irritable bowel syndrome (IBS). We investigated whether polyunsaturated fatty acid (PUFA) metabolites, which activate TRPs, are present in colon tissues from patients with IBS and act as endogenous agonists to induce hypersensitivity.
Keywords AdultAgedAnimalsBiopsyCalcium Channels/metabolismChromatography, LiquidColon/cytology/innervation/metabolismDinoprostone/metabolismFatty Acids, Unsaturated/metabolismFemaleGanglia, Spinal/cytology/metabolismHumansIrritable Bowel Syndrome/metabolismItalyMaleMiceMice, Inbred C57BLMiddle AgedNerve Tissue Proteins/metabolismRNA, Small Interfering/geneticsSensory Receptor Cells/cytology/metabolismSignal TransductionTRPV Cation Channels/metabolismTandem Mass SpectrometryTransient Receptor Potential Channels/metabolismYoung Adult
Identifiers
PMID: 25911511
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CENAC, Nicolas et al. Quantification and Potential Functions of Endogenous Agonists of Transient Receptor Potential Channels in Patients With Irritable Bowel Syndrome. In: Gastroenterology, 2015, vol. 149, n° 2, p. 433-44.e7. https://archive-ouverte.unige.ch/unige:94521

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Deposited on : 2017-05-30

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