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Title

Clinical validity of brain fluorodeoxyglucose positron emission tomography as a biomarker for Alzheimer's disease in the context of a structured 5-phase development framework

Authors
Herholz, Karl
Picco, Agnese
Varrone, Andrea
Nordberg, Agneta
Nobili, Flavio
Published in Neurobiology of Aging. 2017, vol. 52, p. 183-195
Abstract The use of Alzheimer's disease (AD) biomarkers is supported in diagnostic criteria, but their maturity for clinical routine is still debated. Here, we evaluate brain fluorodeoxyglucose positron emission tomography (FDG PET), a measure of cerebral glucose metabolism, as a biomarker to identify clinical and prodromal AD according to the framework suggested for biomarkers in oncology, using homogenous criteria with other biomarkers addressed in parallel reviews. FDG PET has fully achieved phase 1 (rational for use) and most of phase 2 (ability to discriminate AD subjects from healthy controls or other forms of dementia) aims. Phase 3 aims (early detection ability) are partly achieved. Phase 4 studies (routine use in prodromal patients) are ongoing, and only preliminary results can be extrapolated from retrospective observations. Phase 5 studies (quantify impact and costs) have not been performed. The results of this study show that specific efforts are needed to complete phase 3 evidence, in particular comparing and combining FDG PET with other biomarkers, and to properly design phase 4 prospective studies as a basis for phase 5 evaluations.
Identifiers
PMID: 28317648
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Article (Published version) (762 Kb) - document accessible for UNIGE members only Limited access to UNIGE
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Research group Laboratoire de neuroimagerie et de traceurs moléculaires innovants (984)
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GARIBOTTO, Valentina et al. Clinical validity of brain fluorodeoxyglucose positron emission tomography as a biomarker for Alzheimer's disease in the context of a structured 5-phase development framework. In: Neurobiology of Aging, 2017, vol. 52, p. 183-195. https://archive-ouverte.unige.ch/unige:94308

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Deposited on : 2017-05-16

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