UNIGE document Scientific Article
previous document  unige:94297  next document
add to browser collection
Title

Presence of IL-17 in synovial fluid identifies a potential inflammatory osteoarthritic phenotype

Authors
Snelling, Sarah J B
Dakin, Stephanie G
show hidden authors show all authors [1 - 10]
Published in PLOS ONE. 2017, vol. 12, no. 4, p. e0175109
Abstract Osteoarthritis (OA) is a common and heterogeneous arthritic disorder. Patients suffer pain and their joints are characterized by articular cartilage loss and osteophyte formation. Risk factors for OA include age and obesity with inflammation identified as a key mediator of disease pathogenesis. Interleukin-17A (IL-17) is a pro-inflammatory cytokine that has been implicated in inflammatory diseases such as rheumatoid arthritis. IL-17 can upregulate expression of inflammatory cytokines and adipocytokines. The aim of this study was to evaluate IL-17 levels in the synovial fluid of patients with end-stage knee and hip OA in relation to inflammation- and pain-related cytokines and adipocytokines in synovial fluid and serum, and clinical and radiographic disease parameters.
Identifiers
PMID: 28399156
Full text
Article (Published version) (772 Kb) - public document Free access
Structures
Research groups Thérapie cellulaire et troubles musculo-squelettiques (960)
Mécanisme de l'inflammation articulaire (44)
Citation
(ISO format)
SNELLING, Sarah J B et al. Presence of IL-17 in synovial fluid identifies a potential inflammatory osteoarthritic phenotype. In: PLOS ONE, 2017, vol. 12, n° 4, p. e0175109. https://archive-ouverte.unige.ch/unige:94297

36 hits

11 downloads

Update

Deposited on : 2017-05-16

Export document
Format :
Citation style :