Scientific article
OA Policy
English

Presence of IL-17 in synovial fluid identifies a potential inflammatory osteoarthritic phenotype

Published inPloS one, vol. 12, no. 4, e0175109
Publication date2017
Abstract

Osteoarthritis (OA) is a common and heterogeneous arthritic disorder. Patients suffer pain and their joints are characterized by articular cartilage loss and osteophyte formation. Risk factors for OA include age and obesity with inflammation identified as a key mediator of disease pathogenesis. Interleukin-17A (IL-17) is a pro-inflammatory cytokine that has been implicated in inflammatory diseases such as rheumatoid arthritis. IL-17 can upregulate expression of inflammatory cytokines and adipocytokines. The aim of this study was to evaluate IL-17 levels in the synovial fluid of patients with end-stage knee and hip OA in relation to inflammation- and pain-related cytokines and adipocytokines in synovial fluid and serum, and clinical and radiographic disease parameters.

Citation (ISO format)
SNELLING, Sarah J B et al. Presence of IL-17 in synovial fluid identifies a potential inflammatory osteoarthritic phenotype. In: PloS one, 2017, vol. 12, n° 4, p. e0175109. doi: 10.1371/journal.pone.0175109
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Journal ISSN1932-6203
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Creation02/05/2017 16:24:00
First validation02/05/2017 16:24:00
Update time15/03/2023 01:41:29
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