Intravascular device-related infections (IVDRIs) are among the most common nosocomial infections in critically ill patients. Quantitative or semi-quantitative microbiology diagnosis is necessary for their management. Most causative organisms arise from the skin; staphylococci are responsible for two-thirds of the IVDRIs, with Staphylococcus aureus responsible for 5% to 15%. Complications may include septic shock, suppurative thrombophlebitis, and endocarditis. In critically ill patients, intravenous lines are responsible for at least 23% of nosocomial bloodstream infection, which has a mortality of 25% and is associated with a longer stay in intensive care and costs