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Autologous bone marrow-derived cell transplantation in decompensated alcoholic liver disease: what is the impact on liver histology and gene expression patterns?
|Published in||Stem Cell Research and Therapy. 2017, vol. 8, no. 1, p. 88|
|Abstract||Liver stem cell therapy (SCT) has been suggested as a promising means to improve liver regeneration in advanced liver disease. However, data from trials are heterogeneous, with no systematic histological evaluation. The aim of this study is to specifically analyze the effect of autologous SCT on liver regeneration and on gene expression changes.|
|Keywords||Adult — Aged — Antigens, CD/genetics/metabolism — Antigens, CD45/genetics/metabolism — Antigens, Differentiation, Myelomonocytic/genetics/metabolism — Carrier Proteins/genetics/metabolism — Collagen Type I/genetics/metabolism — Female — Hepatocyte Growth Factor/genetics/metabolism — Humans — Liver/metabolism/pathology — Liver Diseases, Alcoholic/therapy — Macrophages/metabolism — Male — Mesenchymal Stem Cell Transplantation/adverse effects — Mesenchymal Stromal Cells/cytology/metabolism — Middle Aged — Serum Amyloid A Protein/genetics/metabolism — Transcriptome — Transplantation, Autologous/adverse effects|
|Research group||Métastases du foie (657)|
|LANTHIER, N et al. Autologous bone marrow-derived cell transplantation in decompensated alcoholic liver disease: what is the impact on liver histology and gene expression patterns?. In: Stem Cell Research & Therapy, 2017, vol. 8, n° 1, p. 88. doi: 10.1186/s13287-017-0541-2 https://archive-ouverte.unige.ch/unige:94214|