Autologous bone marrow-derived cell transplantation in decompensated alcoholic liver disease: what is the impact on liver histology and gene expression patterns?

Lanthier, N; Marq-Lin, Nathalie; Rubbia-Brandt, Laura; Clement, Sophie; Goossens, Nicolas; Spahr, Laurent François Joséph

doi:10.1186/s13287-017-0541-2

Scientific article

English

Autologous bone marrow-derived cell transplantation in decompensated alcoholic liver disease: what is the impact on liver histology and gene expression patterns?

ContributorsLanthier, N; Marq-Lin, Nathalie; Rubbia-Brandt, Laura; Clement, Sophie; Goossens, Nicolas; Spahr, Laurent François Joséph

Published inStem cell research & therapy, vol. 8, no. 1, 88

Publication date2017

Abstract

Liver stem cell therapy (SCT) has been suggested as a promising means to improve liver regeneration in advanced liver disease. However, data from trials are heterogeneous, with no systematic histological evaluation. The aim of this study is to specifically analyze the effect of autologous SCT on liver regeneration and on gene expression changes.

Keywords

Adult
Aged
Antigens, CD/genetics/metabolism
Antigens, CD45/genetics/metabolism
Antigens, Differentiation, Myelomonocytic/genetics/metabolism
Carrier Proteins/genetics/metabolism
Collagen Type I/genetics/metabolism
Female
Hepatocyte Growth Factor/genetics/metabolism
Humans
Liver/metabolism/pathology
Liver Diseases, Alcoholic/therapy
Macrophages/metabolism
Male
Mesenchymal Stem Cell Transplantation/adverse effects
Mesenchymal Stromal Cells/cytology/metabolism
Middle Aged
Serum Amyloid A Protein/genetics/metabolism
Transcriptome
Transplantation, Autologous/adverse effects

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Métastases du foie (657)

Citation (ISO format)

LANTHIER, N et al. Autologous bone marrow-derived cell transplantation in decompensated alcoholic liver disease: what is the impact on liver histology and gene expression patterns? In: Stem cell research & therapy, 2017, vol. 8, n° 1, p. 88. doi: 10.1186/s13287-017-0541-2

Article (Published version)

Identifiers

PID : unige:94214
DOI : 10.1186/s13287-017-0541-2
PMID : 28420441

Journal ISSN1757-6512

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Creation11/05/2017 12:19:00

First validation11/05/2017 12:19:00

Update15/03/2023 01:40:56

Status update15/03/2023 01:40:56

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Autologous bone marrow-derived cell transplantation in decompensated alcoholic liver disease: what is the impact on liver histology and gene expression patterns?

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