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Cholinergic activity correlates with reserve proxies in Alzheimer's disease

Tettamanti, Marco
Marcone, Alessandra
Florea, Ioana
Panzacchi, Andrea
Moresco, Rosamaria
Virta, Jere R
Rinne, Juha
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Published in Neurobiology of Aging. 2013, vol. 34, no. 11, p. 2694.e13-8
Abstract The clinical expression of Alzheimer's disease (AD) occurs as neuropathology exceeds the brain "reserve capacity." A possible association between the cholinergic system and reserve is suggested by preclinical observations that the cholinergic system allows cortical plasticity and by clinical observations of variable responses to cholinergic treatments depending on the patient's educational level. The aim of this study was to investigate the association of reserve proxies, that is, education and occupation, with acetylcholinesterase (AChE) activity, measured voxelwise by [(11)C]-MP4A and positron emission tomography (PET), in 9 healthy controls (HC), 7 patients with early probable AD, and 9 subjects with mild cognitive impairment (MCI) at the time of PET imaging, who progressed to AD at follow-up (prodromal AD). The analysis of prodromal and early AD showed positive correlations between education and AChE activity in the hippocampus, bilaterally, and between occupation and AChE activity in the right posterior cingulate gyrus. The significant correlation between AChE activity in structures belonging to the memory network and reserve proxies suggests that the brain reserve in AD is associated with a preserved/stimulated cholinergic neurotransmission.
Keywords AcetatesAcetylcholine/metabolismAgedAged, 80 and overAlzheimer Disease/diagnostic imaging/physiopathologyCarbon IsotopesCognitive Dysfunction/diagnostic imaging/physiopathologyCognitive Reserve/physiologyEducational StatusEmploymentFemaleFluorodeoxyglucose F18HumansMaleMental Status ScheduleMiddle AgedPiperidinesPositron-Emission TomographyRadiographyStatistics, NonparametricTomography Scanners, X-Ray Computed
PMID: 23820589
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Research group Laboratoire de neuroimagerie et de traceurs moléculaires innovants (984)
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GARIBOTTO, Valentina et al. Cholinergic activity correlates with reserve proxies in Alzheimer's disease. In: Neurobiology of Aging, 2013, vol. 34, n° 11, p. 2694.e13-8. doi: 10.1016/j.neurobiolaging.2013.05.020 https://archive-ouverte.unige.ch/unige:94189

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Deposited on : 2017-05-11

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