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Title

Myelinosome formation represents an early stage of oligodendrocyte damage in multiple sclerosis and its animal model

Authors
Romanelli, Elisa
Mezydlo, Aleksandra
Weil, Marie-Theres
Weber, Martin S
Nikić, Ivana
Potz, Stephanie
Meinl, Edgar
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Published in Nature Communications. 2016, vol. 7, p. 13275
Abstract Oligodendrocyte damage is a central event in the pathogenesis of the common neuroinflammatory condition, multiple sclerosis (MS). Where and how oligodendrocyte damage is initiated in MS is not completely understood. Here, we use a combination of light and electron microscopy techniques to provide a dynamic and highly resolved view of oligodendrocyte damage in neuroinflammatory lesions. We show that both in MS and in its animal model structural damage is initiated at the myelin sheaths and only later spreads to the oligodendrocyte cell body. Early myelin damage itself is characterized by the formation of local myelin out-foldings-'myelinosomes'-, which are surrounded by phagocyte processes and promoted in their formation by anti-myelin antibodies and complement. The presence of myelinosomes in actively demyelinating MS lesions suggests that oligodendrocyte damage follows a similar pattern in the human disease, where targeting demyelination by therapeutic interventions remains a major open challenge.
Identifiers
PMID: 27848954
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Article (Published version) (1.6 MB) - public document Free access
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Research group La Sclérose en plaques (908)
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ROMANELLI, Elisa et al. Myelinosome formation represents an early stage of oligodendrocyte damage in multiple sclerosis and its animal model. In: Nature Communications, 2016, vol. 7, p. 13275. https://archive-ouverte.unige.ch/unige:94181

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Deposited on : 2017-05-11

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