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Nephrotic Syndrome in Small Cell Lung Cancer and Induction of C-Mip in Podocytes

Koessler, Thibaud
Oniszczuk, Julie
Zhang, Shao-Yu
Audard, Vincent
Sahali, Djillali
Published in American Journal of Kidney Diseases. 2017, vol. 69, no. 3, p. 477-480
Abstract Paraneoplastic nephrotic syndrome is often a complication in patients with cancer, and various histologic lesions have been described in the kidney. We report the case of a 76-year-old woman who presented with a podocytopathy that was found to be associated with a small cell lung carcinoma (SCLC). One cycle of carboplatin-etoposide combination therapy led to resolution of nephrotic syndrome and remission of the lung carcinoma. C-Maf-inducing protein (C-Mip) was overexpressed in both podocytes and cancer cells, but was not found in control kidney and lung tissue samples. C-Mip also was absent in SCLC cells from 30 patients without nephrotic syndrome. Exposing cultured podocytes to a sample of our patient's serum that was collected prior to chemotherapy led to disorganization of the podocyte cytoskeleton and induction of C-Mip expression, which was not observed with control serum or our patient's serum sampled after chemotherapy. These observations suggest that C-Mip may play an important role in SCLC-related podocytopathy and that a circulating factor likely induces its expression in the kidney.
PMID: 28063735
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Research groups Insuffisance rénale chronique (941)
Analyse protéomique et Analyse génomique des maladies rénales (659)
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BOUATOU, Yassine et al. Nephrotic Syndrome in Small Cell Lung Cancer and Induction of C-Mip in Podocytes. In: American Journal of Kidney Diseases, 2017, vol. 69, n° 3, p. 477-480. doi: 10.1053/j.ajkd.2016.09.026 https://archive-ouverte.unige.ch/unige:94178

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Deposited on : 2017-05-11

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