Article scientifique

A cross-modal genetic framework for the development and plasticity of sensory pathways

Publié dansNature, vol. 538, no. 7623, p. 96-98
Date de publication2016

Modality-specific sensory inputs from individual sense organs are processed in parallel in distinct areas of the neocortex. For each sensory modality, input follows a cortico-thalamo-cortical loop in which a 'first-order' exteroceptive thalamic nucleus sends peripheral input to the primary sensory cortex, which projects back to a 'higher order' thalamic nucleus that targets a secondary sensory cortex. This conserved circuit motif raises the possibility that shared genetic programs exist across sensory modalities. Here we report that, despite their association with distinct sensory modalities, first-order nuclei in mice are genetically homologous across somatosensory, visual, and auditory pathways, as are higher order nuclei. We further reveal peripheral input-dependent control over the transcriptional identity and connectivity of first-order nuclei by showing that input ablation leads to induction of higher-order-type transcriptional programs and rewiring of higher-order-directed descending cortical input to deprived first-order nuclei. These findings uncover an input-dependent genetic logic for the design and plasticity of sensory pathways, in which conserved developmental programs lead to conserved circuit motifs across sensory modalities.

Citation (format ISO)
FRANGEUL, Laura et al. A cross-modal genetic framework for the development and plasticity of sensory pathways. In: Nature, 2016, vol. 538, n° 7623, p. 96–98. doi: 10.1038/nature19770
Fichiers principaux (1)
Article (Published version)
ISSN du journal0028-0836

Informations techniques

Création09/02/2017 09:39:00
Première validation09/02/2017 09:39:00
Heure de mise à jour15/03/2023 01:40:13
Changement de statut15/03/2023 01:40:13
Dernière indexation30/08/2023 14:42:47
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack