Adrenergic Receptor Polymorphism and Maximal Exercise Capacity after Orthotopic Heart Transplantation

Métrich, Mélanie; Mehmeti, Fortesa; Feliciano, Helene; Martin, David; Regamey, Julien; Tozzi, Piergiorgio; Meyer, Philippe; Hullin, Roger

doi:10.1371/journal.pone.0163475

Scientific article

Open access

English

Adrenergic Receptor Polymorphism and Maximal Exercise Capacity after Orthotopic Heart Transplantation

ContributorsMétrich, Mélanie; Mehmeti, Fortesa; Feliciano, Helene; Martin, David; Regamey, Julien; Tozzi, Piergiorgio; Meyer, Philippe; Hullin, Roger

Published inPloS one, vol. 11, no. 9, e0163475

Publication date2016

Abstract

Maximal exercise capacity after heart transplantion (HTx) is reduced to the 50-70% level of healthy controls when assessed by cardiopulmonary exercise testing (CPET) despite of normal left ventricular function of the donor heart. This study investigates the role of donor heart β1 and β2- adrenergic receptor (AR) polymorphisms for maximal exercise capacity after orthotopic HTx.

Affiliation

Research group

Transplantation et hépatologie (905)

Citation (ISO format)

MÉTRICH, Mélanie et al. Adrenergic Receptor Polymorphism and Maximal Exercise Capacity after Orthotopic Heart Transplantation. In: PloS one, 2016, vol. 11, n° 9, p. e0163475. doi: 10.1371/journal.pone.0163475

Article (Published version)

CC BY

Identifiers

PID : unige:93776
DOI : 10.1371/journal.pone.0163475
PMID : 27669015

ISSN of the journal1932-6203

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Adrenergic Receptor Polymorphism and Maximal Exercise Capacity after Orthotopic Heart Transplantation

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