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Donor-specific antibodies C1q-binding: improvement in kidney graft management?

Published in Transplant International. 2017, vol. 30, no. 4, p. 344-346
Abstract The diagnosis of acute antibody mediated rejection (ABMR) after kidney transplantation is based on three parameters: 1) decreased renal function, 2) histopathological signs of rejection, 3) presence of Donor Specific Antibody (DSA) [1]. Patient survival, as well as graft survival have improved since 5 to 10 years [2], thanks to several factors, including better management of patients, better immunosuppressive regimens, detection and avoidance of DSA. Although anti-HLA antibodies follow-up have improved ABMR management, its treatment remains challenging, and outcome may be worsened because of a delay in the diagnosis. This article is protected by copyright. All rights reserved.
PMID: 28166393
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Research group Transplantation et hépatologie (905)
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FERRARI-LACRAZ, Sylvie. Donor-specific antibodies C1q-binding: improvement in kidney graft management?. In: Transplant International, 2017, vol. 30, n° 4, p. 344-346. https://archive-ouverte.unige.ch/unige:93772

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Deposited on : 2017-04-21

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