Testing of microencapsulated porcine hepatocytes in a new model of fulminant liver failure in baboons

Machaidze, Zurab; Yeh, Heidi; Wei, Lingling; Schuetz, Christian; Carvello, Michele; Sgroi, Antonino; Smith, Rex N; Schuurman, Henk-Jan; Sachs, David H; Morel, Philippe; Markmann, James F; Buehler, Leo Hans

doi:10.1111/xen.12297

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Title		Testing of microencapsulated porcine hepatocytes in a new model of fulminant liver failure in baboons
Authors		Machaidze, Zurab Yeh, Heidi Wei, Lingling Schuetz, Christian Carvello, Michele Sgroi, Antonino Smith, Rex N Schuurman, Henk-Jan Sachs, David H Morel, Philippe Markmann, James F Buehler, Leo Hans show all authors [1 - 12]
Published in		Xenotransplantation. 2017, vol. 24, no. 3, e12297
Abstract		There is no standard therapy for acute liver failure. Hepatocyte transplantation has been proposed for temporary liver function support, while the injured liver regenerates or while waiting for transplantation. We have previously shown such efficacy for microencapsulated porcine hepatocytes in mice with fulminant liver failure. We aimed to establish a large animal model for fulminant liver failure to assess the efficacy of microencapsulated porcine hepatocytes in temporary liver function support.
Keywords		cell microencapsulation — fulminant liver failure — hepatocyte transplantation — non-human primate — porcine hepatocytes
Identifiers		DOI: 10.1111/xen.12297 PMID: 28261903
Full text		Article (Published version) (2.1 MB) - Limited access to UNIGE
Structures		Faculté de médecine / Section de médecine clinique / Département de chirurgie
Research groups		Chirurgie viscérale (104) Chirurgie viscérale (HUG) Transplantation et hépatologie (905)
Citation (ISO format)		MACHAIDZE, Zurab et al. Testing of microencapsulated porcine hepatocytes in a new model of fulminant liver failure in baboons. In: Xenotransplantation, 2017, vol. 24, n° 3, p. e12297. doi: 10.1111/xen.12297 https://archive-ouverte.unige.ch/unige:93756