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Scientific article
English

Testing of microencapsulated porcine hepatocytes in a new model of fulminant liver failure in baboons

Published inXenotransplantation, vol. 24, no. 3, e12297
Publication date2017
Abstract

There is no standard therapy for acute liver failure. Hepatocyte transplantation has been proposed for temporary liver function support, while the injured liver regenerates or while waiting for transplantation. We have previously shown such efficacy for microencapsulated porcine hepatocytes in mice with fulminant liver failure. We aimed to establish a large animal model for fulminant liver failure to assess the efficacy of microencapsulated porcine hepatocytes in temporary liver function support.

Keywords
  • cell microencapsulation
  • fulminant liver failure
  • hepatocyte transplantation
  • non-human primate
  • porcine hepatocytes
Citation (ISO format)
MACHAIDZE, Zurab et al. Testing of microencapsulated porcine hepatocytes in a new model of fulminant liver failure in baboons. In: Xenotransplantation, 2017, vol. 24, n° 3, p. e12297. doi: 10.1111/xen.12297
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Article (Published version)
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Identifiers
ISSN of the journal0908-665X
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